Generation of transgene-free induced Pluripotent Stem Cells (iPSCs) using non-integrative approaches

Understanding the molecular mechanisms of cell reprogramming

Enhancing the efficiency and the kinetics of cell reprogramming

Generation of functional cardiomyocytes from either iPSCs or by direct reprogramming of somatic cells using integrative and non-integrative approaches

Generation of functional insulin producing β-cells from either iPSCs or by direct reprogramming of somatic cells using integrative and non-integrative approaches

Design and development of novel non-integrating vectors for iPSC generation

Investigating the role of core stem cell-specific transcription factors governing stem cell self-renewal, pluripotency and differentiation

Elucidating the epigenetic mechanisms governing stem cell self-renewal, pluripotency and differentiation

Identifying the crucial differences between normal stem cells vs cancer stem cells

Genome editing in pluripotent stem cells

Understanding stem cell heterogeneity