Swaminathan Rajaram



Research Areas:

A. Biophotonics

B. Protein Structure and  Dynamics

C. Proteome Analysis

D. Consequences of molecular crowding inside living cells

Web page:


1. Amrendra Kumar, Shah Ekramul Alom, Dileep Ahari, Anurag Priyadarshi, Mohd. Ziauddin Ansari and Rajaram Swaminathan "Role of Charged Amino acids in Sullying the Fluorescence of Tryptophan or conjugated Dansyl probe in Monomeric Proteins", Biochemistry, DOI.10.1021/acs.biochem.1c00753, Vol.61, 5, P.P 339-353 , (2022)

2. Mohd. Ziauddin Ansari, Shah Ekramul Alom and Rajaram Swaminathan "Ordered structure induced in human c-Myc PEST region upon forming a disulphide bonded dimer", Journal of Chemical Science, DOI.10.1007/s12039-021-01889-3, Vol.133, , P.P - , (2021)

3. Mohd. Ziauddin Ansari, Rajaram Swaminathan "Structure and dynamics at N- and C-terminal regions of intrinsically disordered human c-Myc PEST degron reveal a pH-induced transition. ", Proteins: Structure Function and Bioinformatics, DOI.10.1002/prot.25880, Vol.88, 7, P.P 889-909 , (2020)

4. Amrendra Kumar, Dileep Ahari, Anurag Priyadarshi, Mohd. Ziauddin Ansari and Rajaram Swaminathan "Weak Intrinsic Luminescence in Monomeric Proteins Arising From Charge Recombination", Journal of Physical Chemistry B, DOI.10.1021/acs.jpcb.9b10071, Vol.124, , P.P 2731-2746 , (2020)

5. Anand, R., Agrawal, M., Mattaparthi, V. K. S., Swaminathan, R., Santra, S. B. "Consequences of heterogeneous crowding on an enzymatic reaction: A residence time Monte Carlo approach.", ACS Omega, DOI., Vol.4, , P.P 727-736 , (2019)

6. Ansari, Mohd. Z., A. Kumar, D. Ahari, A. Priyadarshi, L. Padmavathi, R. Bhandari, R. Swaminathan "Protein charge transfer absorption spectra: An intrinsic probe to monitor structural and oligomeric transitions in proteins.", Faraday Discussions, DOI., Vol.207, , P.P 91-113 , (2018)

7. Prasad, S., I. Mandal, S. Singh, A. Paul, B. Mandal, R. Venkatramani, R. Swaminathan "Near UV-Visible electronic absorption originating from charged amino acids in a monomeric protein.", Chemical Science, DOI., Vol.8, , P.P 5416-5433 , (2017)

8. Somaiah C, A. Kumar, D. Mawrie, A. Sharma, S. D. Patil, J. Bhattacharyya, R. Swaminathan, B. G. Jaganathan "Collagen Promotes Higher Adhesion, Survival and Proliferation of Mesenchymal Stem Cells.", PLoS ONE, DOI., Vol.10, 12, P.P e0145068- , (2015)

9. Ravi, V. K., T. Swain, N. Chandra and R. Swaminathan "On the characterization of intermediates in the isodesmic aggregation pathway of hen lysozyme at alkaline pH.", PLoS ONE, DOI., Vol.9, 1, P.P e87256- , (2014)

10. Ravi, V. K., M. Goel, H. C. Kotamarthi, S. R. K. Ainavarapu and R. Swaminathan "Preventing Disulfide Bond Formation Weakens Non-covalent Forces Among Lysozyme Aggregates.", PLoS ONE, DOI., Vol.9, 2, P.P e87012- , (2014)

11. Thokchom, A. K., R. Swaminathan and A. Singh "Fluid Flow and Particle Dynamics Inside an Evaporating Droplet Containing Live Bacteria Displaying Chemotaxis. ", Langmuir, DOI., Vol.30, , P.P 12144-12153 , (2014)

12. Prasad, S. and R. Swaminathan "Measuring the diffusion of fluorescent dye or protein inside living cells.", Curr. Sci., DOI., Vol.105, , P.P 1549-1561 , (2013)

13. Kumar, M. V. S. and R. Swaminathan "A novel approach to segregate and identify functional loop regions in protein structures using their Ramachandran maps. ", Proteins, DOI., Vol.78, , P.P 900-916 , (2010)

14. Kumar, S., Vijay K. Ravi and R. Swaminathan "Suppression of lysozyme aggregation at alkaline pH by tri-N-acetylchitotriose", Biochim. Biophys. Acta (Proteins and Proteomics), DOI., Vol.1794, , P.P 913-920 , (2009)

15. Agrawal, M., S. B. Santra, Rajat Anand and R. Swaminathan "Effect of macromolecular crowding on the rate of diffusion-limited enzymatic reaction", Pramana-J. Phys., DOI., Vol.71, , P.P 359-368 , (2008)

16. Kumar, S., Atul K. Singh, G. Krishnamoorthy and R. Swaminathan "Thioflavin T displays enhanced fluorescence selectively inside anionic micelles and mammalian cells", J. Fluoresc., DOI., Vol.18, , P.P 1199-1205 , (2008)

17. Kumar, S., Vijay K. Ravi and R. Swaminathan "How do surfactants and DTT affect the size, dynamics, activity and growth of soluble lysozyme aggregates?", Biochem. J., DOI., Vol.415, , P.P 275-288 , (2008)

18. Dash, N., F. A. S. Chipem, R. Swaminathan, and G. Krishnamoorthy "Hydrogen bond induced twisted intramolecular charge transfer in 2-(4'-N,N-dimethylaminophenyl)imidazo [4,5-b]pyridine", Chem. Phys. Lett. , DOI., Vol.460, , P.P 119-124 , (2008)

19. Kumar, S. and R. Swaminathan "Employing the fluorescence anisotropy and quenching kinetics of tryptophan to hunt for residual structures in denatured proteins.", J. Chem. Sci., DOI., Vol.119, , P.P 141-145 , (2007)

20. Homchaudhuri, L., Kumar, S. and R. Swaminathan "Slow aggregation of lysozyme in alkaline pH monitored in real time employing the fluorescence anisotropy of covalently labelled dansyl probe.", FEBS Lett., DOI., Vol.580, , P.P 2097-2101 , (2006)

21. Homchaudhuri, L., Sarma, N. and R. Swaminathan "Effect of crowding by dextrans and Ficolls on the rate of alkaline phosphatase-catalysed hydrolysis: A size dependent investigation", Biopolymers, DOI., Vol.83, , P.P 477-486 , (2006)

22. Homchaudhuri, L. and Swaminathan, R. "Near ultraviolet absorption arising from lysine residues in close proximity: A probe to monitor protein unfolding and aggregation in lysine-rich proteins.", Bull. Chem. Soc. Japan, DOI., Vol.77, , P.P 765-769 , (2004)

23. Homchaudhuri, L. and Swaminathan, R. "Novel absorption and fluorescence characteristics of L-lysine ", Chem. Lett., DOI., Vol.2001, , P.P 844-845 , (2001)

24. Partikian, A., B. P. Olveczky, R. Swaminathan, Y. Li, and A. S. Verkman "Rapid diffusion of green fluorescent protein in the mitochondrial matrix. ", J. Cell Biol. , DOI., Vol.140, , P.P 821-829 , (1998)

25. Swaminathan, R., C. P. Hoang and A. S. Verkman "Photobleaching recovery and anisotropy decay of green fluorescent protein GFP-S65T in solution and cells: cytoplasmic viscosity probed by GFP translational and rotational diffusion.", Biophys. J., DOI., Vol.72, , P.P 1900-1907 , (1997)

26. Swaminathan, R. and N. Periasamy "Analysis of fluorescence decay by the maximum entropy method: influence of noise and analysis parameters on the width of the distribution of lifetimes.", Proc. Indian Acad. Sci. (Chem. Sci.) , DOI., Vol.108, , P.P 39-49 , (1996)

27. Swaminathan, R., U. Nath, J. B. Udgaonkar, N. Periasamy and G. Krishnamoorthy "Motional dynamics of a buried tryptophan reveals the presence of partially structured forms during denaturation of Barstar.", Biochemistry, DOI., Vol.35, , P.P 9150-9157 , (1996)

28. Swaminathan, R., S. Bicknese, N. Periasamy and A. S. Verkman "Cytoplasmic viscosity near cell plasma membrane: translational diffusion of a small fluorescent solute measured by total internal reflection-fluorescence photobleaching recovery.", Biophys. J., DOI., Vol.71, , P.P 1140-1151 , (1996)

29. Swaminathan, R., N. Periasamy, J. B. Udgaonkar and G. Krishnamoorthy "Molten globule-like conformation of Barstar: A study by fluorescence dynamics.", J. Phys. Chem., DOI., Vol.98, , P.P 9270-9278 , (1994)

30. Swaminathan, R., G. Krishnamoorthy and N. Periasamy "Similarity of fluorescence lifetime distributions in single tryptophan proteins in the random coil state.", Biophys. J., DOI., Vol.67, , P.P 2013-2023 , (1994)

31. Iyer, A., A. Chandra and R. Swaminathan "Hydrolytic enzymes conjugated to quantum dots mostly retain whole catalytic activity.", Biochim. Biophys. Acta , DOI., Vol.1840, , P.P 2935-2943 , ()

Conference Publication

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Book Chapter

1. Swaminathan, R., V. K. Ravi, S. Kumar, M. V. S. Kumar and N. Chandra "Adv. Protein Chem. Struct. Biol. ", Academic Press. Vol.84, 978-0-12-386483-3, P.P 63-111- , (2011)

2. Chhabra G, N. Chandra, R. Swaminathan "Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives", Springer. Vol., 978-981-10-3706-1, P.P 97-119- , (2017)

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