Biotalk is an extended lecture series spanning the entire academic year organized by Department of Biotechnology, IIT Guwahati. Speakers include, distinguished experts form academia and industry working in the inter-disciplinary areas of biotechnology along with faculty members and research students of the department.
Title of the talk:" Maintenance and Quality Control of Mammalian Gene Expression"
Speaker: Prof. Niels H Gehring, University of Cologne, Germany
Date & Time: 2020-10-16, 5.00PM
Venue : Online: Via MS Team
Abstract of the Talk:
Gene expression in mammals involves several co-transcriptional processing events, including splicing and polyadenylation. Pre-mRNA processing has to occur at the right time and in the right position to produce correct mature RNAs. In the first part of my talk, I will explain how mRNA binding proteins (RBPs) contribute to the identification of correct splice sites. To ensure that proteins are only produced from correct mRNAs, quality control mechanisms constantly monitor each step of gene expression. One of these mechanisms is the nonsense-mediated mRNA decay (NMD) pathway that degrades mRNAs with premature termination codons. In the second part of my talk, I will summarize how cells recognize and degrade erroneous mRNAs