Bio Process Analytical Technology (BIOPAT) Laboratory

Phone: +91-361-2582226 (O)

Email : senthilkumar[AT]

Welcome to BioPAT Lab

News Updates

Our research area is in line with Process Analytical Technology (PAT), an US FDA initiative emphasizing “Building Quality into Products with Innovative Process Design.” PAT is an emerging area of research with the biopharmaceutical industry employing it at different stages such as raw material characterization, in-process monitoring, and final product analysis. Due to the complex and nonlinear characteristics of any bioprocess, monitoring, measuring, modelling, and controlling (M3C) are critical in bioprocess development. Regulatory authorities such as FDA, EMA, and ICH have manifested their interest in M3C methodology in their guidance documents and regulations.

We, as a crew, study the robust manufacturing of bio-therapeutics, biopolymers, and nutraceuticals. Based on the notion of revamping the microbial cells as factories by manipulating their metabolic pathway, optimizing the process conditions, real-time monitoring, and controlling the critical process parameters (CPPs) to boost productivity and achieve consistent product quality. In our BioPAT lab facility, bioprocess development of a product is facilitated via M3C technique. Employing PAT tools such as fermentation calorimeter, dielectric spectroscopy, exhaust gas analyzer, and optical density probe provides real-time metabolic insights into a bioprocess. These tools aid in identifying critical process parameters of the processes. Combining real-time measurements obtained from PAT tools with robust control strategies such as inferential control, adaptive control, model predictive control, and data-driven control ensures a consistent quality of the final product.

» Ph.D Position in BioPAT Laboratory Click here

» Congratulations Dr. Srikanth Katla on starting his career as Principal Scientist at Perfect Day India Pvt. Ltd.

» Hearty wishes to Dr. Naresh Mohan on joining University College London (UCL) as Postdoctoral Research Associate

» Congrats Mr. Ganesh Nehru for his Doctoral thesis submission and wishing him a lot of success and happiness in his future

» Mr.Subbi Rami Reddy Tadi, our greetings on the successful submission of your doctoral synopsis

» Kudos to Dr. Kiran Kumar Gali, Mr. Ganesh Nehru, and Mr. Subbi Rami Reddy Tadi on their recent article publication

» Congratulations Mr. Sivakumar on acquiring the Ph.D position at IIT Delhi

» Hearty wishes to Dr. Kiran Kumar Gali for his graduation

» Congrats to Dr. Rengesh Balakrishnan for joining at Dublin City University as Post-doctoral Fellow

Current Research Area


Biocalorimetry (bench-scale and large-scale biocalorimeters)

BioPAT enabled real-time monitoring and control of bioprocess systems (Biocalorimetry, Dielectric Spectroscopy and Exhaust Gas Analyzer)

Synthesis of recombinant proteins and value-added bioproducts

Mathematical modelling of bioprocess systems

Monitoring and control of environmental bioprocess systems leading to value-added products

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BioProcess Analytical Technology (BioPAT) Laboratory, Department of Biosciences and Bioengineering, IIT Guwahati, Guwahati (Assam)-781039

Phone: +91-361-2582226 (O)

Fax No.: +91-361-2582249 (O)

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