Bio Process Analytical Technology (BIOPAT) Laboratory

Phone: +91-361-2582226 (O)

Email : senthilkumar[AT]

Welcome to BioPAT Lab

News Updates

Our research area is in line with Process Analytical Technology (PAT), an US FDA initiative emphasizing “Building Quality into Products with Innovative Process Design.” PAT is an emerging area of research with the biopharmaceutical industry employing it at different stages such as raw material characterization, in-process monitoring, and final product analysis. Due to the complex and nonlinear characteristics of any bioprocess, monitoring, measuring, modelling, and controlling (M3C) are critical in bioprocess development. Regulatory authorities such as FDA, EMA, and ICH have manifested their interest in M3C methodology in their guidance documents and regulations.

We, as a crew, study the robust manufacturing of bio-therapeutics, biopolymers, and nutraceuticals. Based on the notion of revamping the microbial cells as factories by manipulating their metabolic pathway, optimizing the process conditions, real-time monitoring, and controlling the critical process parameters (CPPs) to boost productivity and achieve consistent product quality. In our BioPAT lab facility, bioprocess development of a product is facilitated via M3C technique. Employing PAT tools such as fermentation calorimeter, dielectric spectroscopy, exhaust gas analyzer, and optical density probe provides real-time metabolic insights into a bioprocess. These tools aid in identifying critical process parameters of the processes. Combining real-time measurements obtained from PAT tools with robust control strategies such as inferential control, adaptive control, model predictive control, and data-driven control ensures a consistent quality of the final product.

» JRF position vacancy on Process Analytical Technology (PAT) control tools for high cell density cultivation of glycoengineered Pichia pastoris for Human Interferon Alpha2b production Click here

» Congratulations Dr. Srikanth Katla on starting his career as Principal Scientist at Perfect Day India Pvt. Ltd.

» Hearty wishes to Dr. Naresh Mohan on joining Massachusetts Institute of Technology (MIT) as Postdoctoral Research Associate

» Congrats Dr. Ganesh Nehru for securing Principal scientist position in Upstream Processing at Shilpa Biologicals Ltd.

» Congrats Dr.Subbi Rami Reddy for securing Scientist position at Biocon Bangalore

» Congrats to Dr. Kiran Kumar Gali for securing Senior Scientist position at Amano Enzyme Inc. Innovation Center, Japan

» Congratulations Dr. Nivedita for joining University college London (UCL) as Postdoctoral fellow

» Congragulations Ms. Sandhya for securing Prime Minister Research fellowship PMRF award Dec 2021

» Congrats to Dr. Rengesh Balakrishnan for joining at Dublin City University as Post-doctoral Fellow

Current Research Area


Biocalorimetry (bench-scale and large-scale biocalorimeters)

BioPAT enabled real-time monitoring and control of bioprocess systems (Biocalorimetry, Dielectric Spectroscopy and Exhaust Gas Analyzer)

Synthesis of recombinant proteins and value-added bioproducts

Mathematical modelling of bioprocess systems

Monitoring and control of environmental bioprocess systems leading to value-added products

Our Gallery


BioProcess Analytical Technology (BioPAT) Laboratory, Department of Biosciences and Bioengineering, IIT Guwahati, Guwahati (Assam)-781039

Phone: +91-361-2582226 (O)

Fax No.: +91-361-2582249 (O)

Copyright @ BioPAT LAB, IIT Guwahati.