Research :: Dr. Anil Kumar Saikia

Research Overview

Professor Saikia has developed several methodologies for the synthesis of heterocyclic compounds using Prins and ene cyclization reactions. Apart from Prins and ene cyclization reactions, intramolecular cyclization reactions of oxygen and nitrogen tethered alkyne/alkenol/thioalkenols are also considered for the synthesis of various heterocyclic compounds. These methodologies have been used for the synthesis of biologically active molecules and natural products. Few oxabicyclic molecules, oxabicyclo[3.3.1]nonanones are found to have antileishmanial activity with IC50 values ranging from 4.95 – 19.52. One of the oxabicyclic compounds PS-203 is found to be effective against a miltefosine-unresponsive strain of the parasite. The combination of hydroxy derivative of PS-203 namely PS-207 with miltefosine showed a synergic effect against the parasite. Some of the natural products and biologically active compounds synthesized using his methodologies are depicted below.

I. Synthesis of oxabicyclo[3.3.1]nonanones

Org. Lett. 2010, 12, 1824.

II. Synthesis of estrogen receptor ligand

Org. Biomol. Chem. 2011, 9, 4626.

III. Synthesis of quinolizidine unnatural alkaloid

J. Org. Chem. 2013, 78, 10629.

IV. Short asymmetric synthesis of (+)-Civet cat compound

J. Org. Chem. 2013, 78, 12182.

V. Diastereoselective Total Synthesis of (+)-epi-Indolizidine 167B and 209D

Org. Biomol. Chem. 2014, 12, 7026.

VI. Synthesis of Substituted Morpholine Derivatives: Total Synthesis of (+)-Viloxazine

Tetrahedron, 2016, 72, 690.

VII. Synthesis of Isochroman Derivatives: Total Synthesis of Sonepiprazole (U-101387)

Synthesis, 2016, 48, 1727.

VIII. Synthesis of Tetrahydro-1H-indeno[1,2-b]pyridine: Synthesis of Antidepressant Agent

J. Org. Chem. 2017, 81, 8736.

IX. Diastereselective Synthesis of Substituted Morpholines from N-Tethered Alkenols: Total Synthesis of (+)- Chelonin A

J. Org. Chem. 2017, 82, 1330.

X. Synthesis of 4-Vinyl-1,2,3,4-tetrahydroisoquinoline from N-Tethered Benzyl-Alkenol: Formal Synthesis of (±)-Isocyclocelabenzine

Synthesis 2020, 52, 1425 (This article is published as a Virtual Thematic Collection of top 20 cited articles published from India in year 2020 and 2021 by Synthesis, DOI: 10.155/s-00000084).

XI. Biologically active molecules

Eur. J. Pharm. Biopharm. 2013, 85, 569.; Lett. Drug Des. Discov. 2014, 11, 937; Antimicrob. Agents Chemother. 2015, 59, 7826; Antimicrob. Agents Chemother. 2018, 62, e01810.