Module A:	Tissue Engineering & Regenerative Medicine in the Nervous System	December 2-6, 2019
Day 1 Date: 2/12/2019 Monday	Overview of Neural Tissue Engineering & Regenerative Medicine (DKC)	Lecture 1: 9:30 to 10:30 AM Introduction to tissue engineering and regenerative medicine concepts and strategies intreating nervous system disorders, including historical perspectives and state-of-the art. Lecture 2: 10:45 to 11:45 AM Exploration of emerging strategies, technologies, and trends in nervous system repair, reconstruction, and functional restoration. Tutorial 1: 2:00 to 4:00 PM. Hand out the first assignment.
Day 2 Date: 3/12/2019 Tuesday	Biomaterials & Acellular Scaffolds in Neural Tissue Engineering (UB)	Lecture 3: 9:30 to 10:30 AM Principles of material selection, chemistry, and fabrication procedures; Generation of polymer-based scaffolds for neural tissue engineering applications. Lecture 4: 10:45 to 11:45 AM Applications of acellular scaffolds in tissue engineering and regeneration, including controlled drug delivery, modulation of inflammation, degradation/remodeling, and cell recruitment.
Day 3 Date: 4/12/2019 Wednesday	Cell Replacement Strategies & Cell-Based Scaffolds in Tissue Engineering (DKC)	Lecture 5: 9:30 to 10:30 AM Principles of cell replacement and cell engineering, including source (stem cells, primary/ secondary, cell lines), immunological (autologous, allogeneic, xenogeneic), and reprogramming (genetic manipulation). Lecture 6: 10:45 to 11:45 AM Techniques to create 3D cell-based constructs and anatomically-inspired “living scaffolds”, including matrix/polymer encapsulation, mechanical “stretch-growth” of axonal tracts, encasement schemes for neuronal/glial network self-assembly, 3D bio-printing techniques, and bioreactor designs.
Day 4 Date: 5/12/2019 Thursday	Tissue Engineering Applications for Peripheral Nerve Repair (DKC)	Lecture 7: 9:30 to 10:30 AM Introduction to peripheral nervous system (PNS) injury, including causation, incidence, pathophysiology, and endogenous regenerative capacity; discussion of current clinical repair strategies, unmet needs, and preclinical modeling considerations. Lecture 8: 10:45 to 11:45 AM Future clinical potential and repair mechanisms of tissue engineering strategies to facilitate nerve regeneration and augment functional recovery following major PNS trauma; focus on tissue engineered “living scaffolds” to drive long-distance axonal regeneration.
Day 5 Date: 6/12/2019 Friday	Tissue Engineering Applications for Central Nervous System Repair (DKC)	Lecture 9: 9:30 to 10:30 AM Introduction to central nervous system (CNS) injury and neurodegeneration, including causes, incidence, and pathophysiology; discussion of current clinical management strategies, unmet needs, and preclinical modeling considerations. Lecture 10: 10:45 to 11:45 AM Future clinical potential and repair mechanisms of tissue engineering strategies to facilitate regeneration following CNS trauma or neurodegenerative disease; focus on “living scaffolds” to direct endogenous stem cell migration and micro-tissue engineered neural networks to reconstruct lost brain circuitry; Summary of Module A and feedback. Submission of first assignment.