Bioorganic Chemistry Research Laboratory @ IITG
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Bioorganic Chemistry Research Laboratory @ IITG
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Research Output before joining IIT Guwahati


22.   Bhabak, K. P.; Hauser, A.; Redmer, S.; Banhart, S.; Heuer, D.; Arenz, C.* "Development of a Novel FRET Probe for the Real-Time Determination of     
        Ceramidase Activity"  ChemBioChem   2013,   14,   1049-1052.
        (This work has been featured on the Cover Page of the Journal)

21.    Bhabak, K. P.; Arenz, C.* "Novel Drugs Targeting Sphingolipid Metabolism", In Sphingolipids: Basic Science and Drug Development In  Handbook Exp.
         Pharmacol. Eds. Gulbins, E.; Petrache, I., Springer-Verlag Wien, 2013215,   p187-196 (Book Chapter).

20.    Bhabak, K. P.; Bhowmick, D.; Mugesh, G.* "Synthetic glutathione peroxidase mimics: Effect of nucleophilicity of the aryl thiol cofactor on the antioxidant
         activity"  Ind. J. Chem. A   2013,   52A,   1019-1025.

19.    Bhabak, K. P.; Kleuser, B.; Huwiler, A.; Arenz, C.* "Effective Inhibition of Acid and Neutral Ceramidases by Novel B-13 and LCL-464 Analogues"
     Bioorg. Med. Chem.   2013,   21,   874-882.


18.    Bhabak, K. P.; Arenz, C.*"Novel Amide- and Sulfonamide-based B-13 and D-MAPP Analogues: Effect of Aromatic Substituents on the Inhibition of Acid and
         Neutral Ceramidases" Bioorg. Med. Chem.   2012,   20,   6162-6170.

17.    Bhabak, K. P.; Proksch, D.; Redmer, S.; Arenz, C.*"Novel Fluorescent Ceramide Derivatives for Probing Ceramidase Substrate Specificity"
       Bioorg. Med. Chem.   2012,   20,   6154-6161.

16.   Bhabak, K. P.;* Debasish Bhowmick "Synthesis and Structural Characterization of some Trisulfide Analogues of Thiourea-based Antithyroid Drugs."
      J. Mol. Struct.   20121022,   16-24.

15.    Bhabak, K. P.; Mugesh, G.* "Synthetic Mimics of Selenoproteins" In Selenoproteins and Mimics Eds. Liu, J.; Luo, G., Zhejiang University Press,
         Hangzhou and Springer-Verlag Berlin Heidelberg  2012,  p207-221 (Book Chapter)


14.    Bhabak, K. P.; Mugesh, G.* "Gold(I)-Selenolate Complexes: Synthesis, Characterization and Ligand Exchange Reactions"
          J. Chem. Sci.   2011, 123,   783-789.

13.   Bhabak, K. P.; Satheeshkumar, K.; Jayavelu, S.; Mugesh, G.* "Inhibition of Peroxynitrite- and Peroxidase-mediated Protein Tyrosine Nitration by
        Imidazole-based Thiourea and Selenourea Derivatives" Org. Biomol. Chem.   20119,   7343-7350.

12.    Bhabak, K. P.; Mugesh, G.* "Synthesis and Characterization of Some Gold(I)-Thiolate Complexes Having N-Methylimidazole Moiety"
        Ind. J. Chem. 2011,   50A,   1303-1307.

11.    Roy, G.; Bhabak, K. P.; Mugesh, G.* "Interactions of Antithyroid Drugs and their Analogues with Halogens and their Biological Implications"
          Crystal Growth & Design,   2011, 11,   2279-2286.

10.    Bhabak, K. P.; Vernekar, A. A.; Jakka, S. R.; Roy, G.; Mugesh, G.* "Mechanistic Investigations on the Efficient Catalytic Decomposition of Peroxynitrite by
         Ebselen Analogues" Org. Biomol. Chem.  20119,   5193-5200.

09.    Bhabak, K. P.; Bhuyan, B. J.; Mugesh, G.* "Bioinorganic and Medicinal Chemistry: Aspects of Gold(I)-Protein Complexes."
        Dalton Trans.  201140,   2099-2111.


08.    Bhabak, K. P.; Mugesh, G.* "Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants."
        Acc. Chem. Res.  201043,   1408-1419.
           (This work has been featured on the Cover Page of the Journal)

07.   Bhabak, K. P.; Mugesh, G.* "Inhibition of Peroxidase-catalyzed Protein Tyrosine Nitration by Antithyroid Drugs and their Analogues."
       Inorg. Chim. Acta  2010363,   2812-2818.

06.    Bhabak, K. P.; Mugesh, G.* "Antithyroid Drugs and their Analogues Protect Against Peroxynitrite-Mediated Protein Tyrosine Nitration -A Mechanistic Study."
      Chem. Eur. J.  201016,   1175-1185.
        (This work has been featured on the Cover Page of the Journal)


05.    Bhabak, K. P.; Mugesh, G.* "Synthesis and Structure-Activity Correlation Studies of Secondary and Tertiary Amine-based Glutathione Peroxidase Mimics."
      Chem. Eur. J.   200915,   9846-9854.

04.   Bhabak. K. P.; Mugesh, G.* "A Synthetic Model for the Inhibition of Glutathione Peroxidase by Antiarthritic Gold Compounds."
      Inorg. Chem.   200948,   2449-2455.

03.    Bhabak, K. P.; Mugesh, G.* "Amide-Based Glutathione Peroxidase Mimics: Effect of Secondary and Tertiary Amide Substituents on Antioxidant Activity."
        Chem. Asian J.   20094,   974-983.


02.   Bhabak, K. P.; Mugesh, G.* "A Simple and Efficient Strategy To Enhance the Antioxidant Activities of Amino-Substituted Glutathione Peroxidase Mimics."
          Chem. Eur. J.   200814,   8640-8651.


01.   Bhabak, K. P.; Mugesh, G.* "Synthesis, Characterization and Antioxidant Activity of Some Ebselen Analogues."
    Chem. Eur. J.   200713,   4594-4601.


17. Bhabak, K. P. (2023): Delivered an Invited Lecture in the Short Term Training Programme on "DRINKING WATER QUALITY AND PUBLIC HEALTH (PS21B)"  at NITTTR, Kolkata during 22 May - 02 June, 2023.

16. Bhabak, K. P. (2023): Delivered an Invited Lecture in the international symposium "Emerging Trends in Chemical Sciences-2023 (ETCS-2023)" at NEHU, Shillong, Meghalaya, during 2-4 March, 2023.

15. Bhabak, K. P. (2022): Delivered an Invited Leture in the international symposium "Frontiers in Chemical Sciences-2022 (FICS-2022)" at IIT Guwahati during 2-4 December, 2022.

14. Bhabak, K. P. (2022): Delivered a Departmental Lecture at the Department of Chemistry, IIT Madras during 23 September, 2022.

13. Bhabak, K. P. (2022): Delivered an Invited Lecture at CSIR-Central Leather Research Institute (CLRI) on the occasion of the "Celebration of 75th Foundation Day of the Institute" during 22 September, 2022.

12. Bhabak, K. P. (2020): Delivered an Invited Lecture in "Diversity in Catalytic Approaches" at National Institute of Technology, Manipur (NIT Manipur) during 27-31 October, 2020.

11.  Bhabak, K. P. (2017): Participated and presented a Poster in "INSPIRE Faculty Monitoring-cum-Interaction Meet" in the subject area of Chemical Sciences & Material Sciences at the KIIT University, Bhubaneswar, Odisha during 16-17th Jan 2017.

10.  Bhabak, K. P. (2016): Invited lecture in KIC TEQIP Short term Course on 'Recent Trends in Catalysis' in Department of Chemistry, IIT Guwahati during 13-14th May, 2016.

09. Bhabak, K. P. (2015): Participated and presented a Poster in the National Conference "New Frontiers in Chemistry -- From Fundamentals to Applications" (NFCFA2015)" in Department of Chemistry, BITS Pilani KK Birla Goa Campus during 18-19 December, 2015.

08. Bhabak, K. P. (2015): Participated and presented a Poster in "Networking-Cum-Discussion Meet" for existing INSPIRE Faculty Awardees at Tezpur University, Tezpur, Assam, India during 20-21st March, 2015.

07. Bhabak, K. P. (2014): Participated and presented a Poster in "2nd International Symposium on Emerging Trends in Chemical and Pharmaceutical Sciences and Pharma. Chem. Expo-2014" at Indian Institute of Chemical Technology (IICT), Hyderabad, India during October 15-17, 2014.

06. Bhabak, K. P. (2014): Participated in "16th CRSI National Symposium in Chemistry (NSC-16)" in Department of Chemistry, Indian Institute of Technology Bombay (IITB), India during 7-9th Feb 2014.

05.  Bhabak, K. P. (2013): "Real-Time Determination of Ceramidase Activity by Novel FRET-based Substrate Analogues" participated and delivered Oral Presentation in the UGC-sponsored National Symposium on "Current Trends in Chemistry" in Department of Chemistry, Sripat Singh College, Murshidabad, West Bengal, India during 23-24th Dec, 2013.

04.  Bhabak, K. P.; Arenz, C. (2012): "Development of novel fluorescent ceramide analogues for the inhibition of ceramidase activity" Presented Poster on Challenges in Bioorganic & Organic Medicinal Chemistry at 13th Tetrahedron Symposium on 26-29 June 2012, Amsterdam, Netherlands.

03.  Bhabak, K. P.; Arenz, C. (2011): "Inhibition of Ceramidase Activity by Novel B-13 Analogues" Presented a Poster at the "1st Bonn Humboldt Award Winners" Forum of the Alexander von Humboldt Foundation" at Bonn, GERMANY.

02. Bhabak, K. P.; Mugesh, G. (2008): "Antithyroid Drugs and Related Compounds Effectively Protect Against Peroxynitrite-mediated and Peroxidase-catalyzed Nitration and Oxidation Reactions" Presented a Poster at the "10th CRSI National Symposium in Chemistry" at Indian Institute of Science (IISc), Bangalore, INDIA.

01.  Bhabak, K. P.; Mugesh, G. (2007): "Antithyroid Drugs and Related Compounds Effectively Protect against Heme-Peroxidase-catalyzed Nitration Reactions" Presented a Poster at the "Modern Trends in Inorganic Chemistry-XII (MTIC-XII) at Indian Institute of Technology (IIT) Madras, INDIA.

Research Output after joining IIT Guwahati
23.    Bhabak, K. P.*; Bhowmick, D. "Synthetic strategies of gold(I)-selenolates from ortho-substituted diaryl diselenides via selenol and selenenyl sulfide intermediates" Inorg. Chim. Acta, 2016, 450, 337-345.
24.    Bhattacherjee, D.; Bhabak, K. P.* "Atom based 3D-QSAR studies on 2,4-dioxopyrimidine-1-carboxamide analogs: Validation of experimental inhibitory potencies towards acid ceramidase"   Eur. J. Pharm. Sci. 2016, 83, 8-18. 
25.    Saha, M.; Vyas, K. M.; Martins, L. M.; Martins, N. M. R.;  Pombeiro, A. J. L.; Mobin, S. M.; Bhattacherjee, D.; Bhabak, K. P.; Mukhopadhyay, S. "Copper (II) tetrazolato complexes: Role in oxidation catalysis and protein binding" Polyhedron, 2017, 132, 53-63.

26.    Bhattacherjee, D.; Basu, C.; Bhardwaj, Q.; Mal, S.; Sahu, S.; Sur, R.; Bhabak, K. P.*   "Design, Synthesis and Anti-Cancer Activities of Benzyl Analogues of Garlic-Derived Diallyl Disulfide (DADS)and the Corresponding Diselenides" ChemistrySelect, 2017, 2, 7399-7406.      

27.     Mandal, P.; Kundu, B. K.; Vyas, K.; Sabu, V.; Helen, A.;  Dhankhar, S. S.; Nagaraja, C. M.; Bhattacherjee, D.; Bhabak, K. P.; Mukhopadhyay, S.*  "Ruthenium(II) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines" Dalton Trans., 2018, 47, 517-527.

28.    Banerjee, K.; Padmavathi, G.; Bhattacherjee, D.; Saha, S.; Kunnumakkara, A. B.; Bhabak, K. P.*  "Potent Anti-proliferative Activities of Organochalcogenocyanates towards Breast Cancer" Org. Biomol. Chem. 2018, 16, 8769-8782.

30.    Bhattacherjee, D.; Sufian, A.;§ Mahato, S. K.;§ Begum, S.;§ Banerjee, K.; De, S.; Srivastava, H. K.* Bhabak, K. P.* "Trisulfides over disulfides: highly selective synthetic strategies, anti-proliferative activities and sustained H2S release profiles" Chem. Commun. 2019, 55, 13534-13537.
    [§contributed equally to the work]
29.    Malviya, N.; Sonkar, C.; Ganguly, R.; Bhattacherjee, D.; Bhabak, K. P.; Mukhopadhyay, S.* "Novel Approach to Generate Self-Deliverable Anticancer Ru(II) agent in the Self-Reacting Confined Gel Space" ACS Appl. Mater. Interfaces, 2019, 11, 47606-47618.

31.    Mahato, S. K.; Bhattacherjee, D.; Bhabak, K. P.* "Biothiol-triggered Organotrisulfide-based Self-immolative Fluorogenic Donors of Hydrogen Sulfide Enabling Lysosomal Trafficking" Chem. Commun. 202056, 7769-7772.
32.    Sufian, A.; Bhattacherjee, D.; Mishra, T.; Bhabak, K. P.* "Peroxide-responsive boronate ester-coupled turn-on fluorogenic probes: Direct linkers supersede self-immolative linkers for sensing peroxides" Dyes Pigm. 2021191, 109363.

1.   Bhabak, K. P., Mahato, S. K., Bhattacherjee, D., Barman, P. "Nucleophile-sensitive Fluorogenic Probes and    Donors of Hydrogen Sulfide and Method of Synthesis" Patent Application No: 202231008664; Date: Feb 18, 2022.

2.   Bhabak, K. P. and Banerjee, K. "Heterocyclic Ionic Organoselenium Compounds and Method of Synthesis" Patent Application No: 202131030739; Date: June 08, 2021.

34.    Banerjee, K.; Bhattacherjee, D.; Mahato, S. K.; Sufian, A.; Bhabak, K. P.* "Benzimidazole-and Imidazole-Fused Selenazolium and Selenazinium Selenocyanates: Ionic Organoselenium Compounds with Efficient Peroxide Scavenging Activities" Inorg. Chem.  202160, 12984-12999.
33.    Ghosh, S.;§Bhattacherjee, D.;§Satpati, P.*; Bhabak, K. P.* "Venetoclax: a promising repurposed drug against SARS-CoV-2 main protease" J. Biomol. Struct. Dyn. 2021 (DOI:
[§: Contributed equally to this work]
36.    Banerjee, K.; Bhattacherjee, D.;ξ Raina, K.;ξ Thummer, R. P.*; Bhabak, K. P.* "Benzimidazole-based Ionic and Non-ionic Organoselenium Compounds: Innovative Synthetic Strategies, Structural Characterizations and Preliminary Anti-Proliferative Activities" New J. Chem. 202246, 11910-11926.
[ξ contributed equally to the work]
35.    Mahato, S. K.; Bhattacherjee, D.; Barman, P.; Bhabak, K. P.* "Thioredoxin reductase-triggered fluorogenic donor of hydrogen sulfide: a model study with a symmetrical organopolysulfide probe with turn-on near-infrared fluorescent emission" J. Mater. Chem. B202210, 2183-2193.

37.    Sufian, A.; Bhattacherjee, D.; Barman, P.; Srivastava, A.; Thummer, R. P.; Bhabak, K. P.* "Stimuli-responsive prodrug of non-steroidal anti-inflammatory drug diclofenac: self-immolative drug release with turn-on near-infrared fluorescence" Chem. Commun. 202258, 7833-7836.

39.    Bhattacherjee, D.; Raina, K.; Mandal, T. K.; Thummer, R. P.*; Bhabak, K. P.* "Targeting Wnt/β-catenin signaling pathway in triple-negative breast cancer by benzylic organotrisulfides: Contribution of the released hydrogen sulfide towards potent anti-cancer activity" Free Radic. Biol. Med. 2022191, 82-96.

38.    Ravula, R.; Bhabak, K. P.; Mandal, T. K.* "User-friendly point of care test device for detection of arsenic in potable water: Prototype, design, and artifact" Asia-Pac. J. Chem. Eng2022, 17e2815. doi:10.1002/apj.2815

42.    Sufian, A.; Badirujjaman, Md.;ξ Barman, P.;ξ Bhabak, K. P.* "Dual-Stimuli-Activatable Hybrid Prodrug for the Self-Immolative Delivery of an Anticancer Agent and Hydrogen Sulfide with Turn-on Fluorescence" Chem. Eur. J. 2023 (
[ξ Contributed equally to the work]
40.    Badirujjaman, Md.;ξ Pal, N.;ξ Bhabak, K. P.* "Small-molecule Organoselenocyanates: Recent Developments toward Synthesis, Anticancer and Antioxidant Activities" Curr Opin Chem Biol, 2023 (Accepted article)
[ξ: contributed equally]                               (Invited mini-review in the themed issue on Sulfur and Selenium)

41.    Mahato, S. K.; Barman, P.; Badirujjaman, Md.; Bhabak, K. P.* "Cysteine-responsive prodrug of the anti-cancer drug amonafide: fluorogenic adjuvant drug delivery with hydrogen sulfide (H2S)" Chem. Commun., 202359, 4802-4805.