Welcome to
     Biological Chemistry Laboratory
                                     ... webpage of  Dr. Debasis Manna
Publications     
23. Nitrobenzofurazan derivatives of N'-hydroxyamidines as potent inhibitors of indoleamine-2,3-dioxygenase 1
                                        Paul, S.+; Roy, A.+; Deka, S. J.; Panda, S.; Trivedi, V.*; Manna, D.*
                                        European Journal of Medicinal Chemistry, 2016, 121, 364-375.
22. 3-Amino-4-Aminoximidofurazan derivatives: small molecules possessing antimicrobial and antibiofilm activity against Staphylococcus aureus and Pseudomonas aeruginosa
                                        Das, M. C; Paul, S.; Gupta, P.; Tribedi, P.; Sarkar, S.; Manna, D.*; Bhattacharjee, S.*
                                        Journal of Applied Microbiology, 2016, 120 (4), 842-859.
21. Mechanistic Insights into the Phosphatidylinositols Binding Properties of Pleckstrin Homology Domain of Lamellipodin
                                        Gorai, S.; Paul, D.; Haloi, N.;  Borah, R.; Santra, M. K.*; Manna, D.*
                                        Molecular BioSystems, 2016, 12, 747-757.
20. Inhibition of Phosphatidylinositol-3,4,5-trisphosphate Binding to AKT Pleckstrin Homology Domain by 4-Amino-1,2,5-oxadiazole Derivatives
                                        Gorai, S.; Paul, S.; Sankaran, G.;  Borah, R.; Santra, M. K.*; Manna, D.*
                                        Medicinal Chemical Communications, 2015, 6 (10), 1798-1808.
19. Insights into the Inhibitory mechanism of Triazole-Based Small Molecules on Phosphatidylinositol-4,5-bisphosphate Binding Pleckstrin Homology Domain
                                        Gorai, S.; Ray Bagdi, P.; Borah, R.;Paul, D.; Santra, M. K.; Khan, A. T.; Manna, D.*
                                        Biochemistry and Biophysics Reports, 2015, 2,75-86.
18. Elucidating the Interaction of γ-Hydroxymethyl-γ-butyrolactone Substituents with Model Membranes and Protein Kinase C-C1 Domains
                                        Borah, R.+; Mamidi, N.+; Panda, S.; Gorai, S.; Pathak, K., S.; Manna, D.*
                                        Molecular Biosystems, 2015, 11 (5), 1389-1399. (+, Equal Contribution)
17. Synthesis and Protein Kinase C (PKC)-C1 Domain Binding Properties of Diacyltetrol Based Anionic Lipids.
                                         Mamidi, N.+; Panda, S.+; Borah, R.; Manna, D.*
                                         Molecular Biosystems, 2014, 10 (11), 3002-3013. (+, Equal Contribution)
16. Membrane Interaction and Protein Kinase C-C1 Domain Binding Properties of 4-hydroxy-3-(hydroxymethyl) Phenyl ester Analogues
                                        Talukdar, D.+;  Panda, S.+; Borah, R.+; Manna, D.*
                                        Journal of Physical Chemistry B, 2014, 118 (27), 7541-7553. (+, Equal Contribution)
15. Bilayer Interaction and Protein Kinase C-C1 Domain binding studies of Kojic Acid Esters.
                                        Borah, R.; Talukdar, D.; Gorai, S.; Bain, D.; Manna, D.*
                                        RSC Advances, 2014, 4, 25520-25531. 
14. Physicochemical Characterization of Diacyltetrol-Based Lipids consisting of both Diacylglycerol and Phospholipid headgroups
                                        Mamidi, N.+; Gorai, S.+; Ravi, B.; Manna, D.*
                                        RSC Advances, 2014, 4, 21971-21978. (+ Equal Contribution))
13. Mild method for the synthesis of 1H-indazoles through oxime-phosphonium ion intermediate.
                                         Paul, S.; Panda, S.; Manna, D.*
                                        Tetrahedron Letters, 2014, 55, 2480-2483.
                                        (Highlighted as Selected Abstracts in Chemistry: "ChemInform Abstract: Mild method for the synthesis of 1H-indazoles through     oxime-phosphonium ion intermediate "ChemInform, 2014, 45 (38) September 4, 2014)
12. Zn(OTf)2 Promoted Chemoselective Esterification of Hydroxyl Group Bearing Carboxylic Acids
                                         Mamidi, N.; Manna, D.*
                                        Journal of Organic Chemistry, 2013, 78 (6), 2386-2396.
                                        (Highlighted as Selected Abstracts in Chemistry: "ChemInform Abstract: Zn(OTf)2-Promoted Chemoselective Esterification of Hydroxyl Group Bearing Carboxylic Acids" ChemInform, 2013, 44 (28) July 9, 2013.
Highlighted in Catalysts & Catalysed Reactions databses, 26642, 2013)
11. Effects of Ortho-Substituent Groups of Protocatechualdehyde Derivatives on Binding to the C1 Domain of Novel Protein Kinase C
                                         Mamidi, N.; Borah, R.; Sinha, N.; Jana, C.; Manna, D.*
                                        Journal of Physical Chemistry B, 2012, 116(35), 10684-92.
10.   Development of diacyltetrol lipids as activators for the C1 domain of protein kinase C
                                        Mamidi, N.; Gorai, S.; Mukherjee, R.; Manna, D.*
                                       Molecular Biosystems, 2012, 8, (4), 1275-1285.
9.  Structural and functional consequences of mutating a proteobacteria-specific surface residue in the catalytic domain of Escherichia coli GluRS
                                        Dasgupta, S.; Manna, D.; Basu, G.*
                                       FEBS Letters, 2012, 586, (12), 1724-1730.
8.   DNA binding, nuclease activity and cytotoxicity studies of Cu(II) complexes of tridentate ligands
                                        Kumar, P.; Gorai, S.; Santra, M.; Mondal, B.*; Manna, D.*
                                       Dalton Transactions, 2012, 41, (25), 7573-7581.
7.   Alkyl cinnamates as regulator for the C1 domain of protein kinase C isoforms.
                                        Mamidi, N.; Gorai, S.; Sahoo, J.; Manna, D.*
                                        Chemistry and Physics of Lipids, 2012, 165, (3), 320-330.
6.   DNA binding and nuclease activity of copper(II) complexes of tridentate ligands.
                                        Kumar, P.; Baidya, B.; Chaturvedi, S. K.; Khan, R. H.; Manna, D.*; Mondal, B.*
                                       Inorganica Chimica Acta, 2011, 376, (1), 264-270.
5.   Microplate-Based Characterization of Protein-Phosphoinositide Binding Interactions Using a Synthetic Biotinylated Headgroup Analogue
                                        Gong, D. H.; Smith, M. D.; Manna, D.; Bostic, H. E.; Cho, W.; Best, M. D.*
                                        Bioconjugate Chemistry, 2009, 20, (2), 310-316.
4.   Differential roles of phosphatidylserine, PtdIns(4,5)P(2), and PtdIns(3,4,5)P(3) in plasma membrane targeting of C2 domains - Molecular dynamics simulation, membrane binding, and cell translocation studies of the PKC alpha C2 domain
                                        Manna, D.; Bhardwaj, N.; Vora, M. S.; Stahelin, R. V.; Lu, H.; Cho, W.*
                                        Journal of Biological Chemistry, 2008, 283, (38), 26047-26058.
3.   Unexpected complexity in the mechanisms that target assembly of the spectrin cytoskeleton
                                        Das, A.; Base, C.; Manna, D.; Cho, W.; Dubreuil, R. R.*
                                        Journal of Biological Chemistry, 2008, 283, (18), 12643-12653.
2.   Real-time cell assays of phospholipase A(2)s using fluorogenic phospholipids
                                        Manna, D.; Cho, W.*,
                                        Methods in Enzymology, 2007, 434, 15-27.
1.   Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains
                                        Manna, D.; Albanese, A.; Park, W. S.; Cho, W.*
                                       Journal of Biological Chemistry, 2007, 282, (44), 32093-32105.



28. Danazol has potential to cause pkc translocation, cell-cycle dysregulation and apoptosis in breast cancer cells
                                        Deka, S. J.; Roy, A.; Ramakrishnan, V.; Manna, D.; Trivedi, V*
                                        Chemical Biology & Drug Design, 2017, 89 (6), 953-963.
27. Evidence of PKC Binding and Translocation to explain the anticancer mechanism of chlorogenic acid in breast cancer cells
                                        Deka, S. J.; Gorai, S.; Manna, D.; Trivedi, V*
                                        Current Molecular Medicine,  2017, 17 (1), 79-89.
26. Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis
                                        Deka, S. J.; Mamdi, N.; Manna, D.; Trivedi, V*
                                        Journal of Breast Cancer, 2016, 19 (4), 358-371
25. Fused heterocyclic compounds as potent indoleamine-2,3-dioxygenase 1 inhibitors
                                        Panda, S.+; Roy, A.+; Deka, S. J.; Trivedi, V.; Manna, D.*
                                        ACS Medicinal Chemistry Letters, 2016, Advance Article (+,
24. Phosphate bioisostere containing amphiphiles: a novel class of squaramide-based lipids
                                        Saha, A.+; Panda, S.+; Paul, S.+; Manna. D*
                                        Chemical Communications, 2016, 52, 9438-9441 (+, Equal Contribution)
31. Identification of Substituted 1H-Indazoles as Potent Inhibitors for Immunosuppressive Enzyme Indoleamine 2, 3-Dioxygenase 1
                                            Pradhan, N.; Paul, S.; Deka, S. J.; Roy, A.; Trivedi, V.; Manna, D. *
                                            Chemistry Select, 2017, 2 (20), 5511-5517.
30. Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2, 3-dioxygenase 1
                                            Paul, S.; Roy, A.; Deka, S. J.; Panda,  S.; Srivastava, G. N.; Trivedi, V.; Manna, D. *
                                            Med Chem Comm, 2017, 8 (8), 1640-1654.
29.Transition metal, azide and oxidant free homo- and heterocoupling of ambiphilic tosylhydrazones to the regioselective triazoles and pyrazoles
                                           Panda, S.; Maity, P.*; Manna, D.*
                                           Organic Letters, 2017, 19 (7), 1534–1537.
37. Ring-opening of Indoles: An Unconventional Route for the Transformation of Indoles to 1H-Pyrazoles using Lewis Acid
                                            Panda, S.; Pradhan, N.; Manna. D.*
                                            ACS Combinatorial Science, 2018, 20 (10), 573-578.
36. Effect of Molecular Crowding Agents on the Activity and Stability of Immunosuppressive Enzyme Indoleamine 2, 3-Dioxygenase 1
                                            Roy, A.; Das, S.; Manna. D.*
                                            Chemistry Select, 2018, 3 (23), 6294-6301.
35. Biochemical Studies and Virtual Screening of Phytochemical Reservoir from Northeastern Indian Plants to Identify Anti-Cancer Agents
                                            Deka. J. S.; Ghorai, S.; Manna, D.; Trivedi, V.*
                                            Journal of Biologically Active Products from Nature, 2018, 8 (2), 104-124.
34. Role of Cationic Groove and Hydrophobic Residues in Phosphatidylinositol-Dependent Membrane-Binding Properties of Tks5-Phox Homology Domain
                                            Gorai, S.; Paul, D.; Borah, R.; Haloi, N.; Santra, K. M.; Manna. D.*
                                            Chemistry Select, 2018, 3 (4), 1205-1214.
33. Integrating virtual screening and biochemical experimental approach to identify potential anti-cancer agents from drug databank
                                            Deka. J. S.; Roy, A.; Manna, D.; Trivedi, V.*
                                            Journal of bioinformatics and computational biology, 2018, 16(3), 1850002.
32. Azidophosphonate chemistry as route for a novel class of vesicle forming phosphonolipids
                                            Saha, A.+; Panda, S.+; Pradhan, N.; Kalita, K.; Vishal, T.; Manna. D.*
                                            Chemistry-A European Journal, 2018, 24 (5), 1121-1127.
                                            (+, Equal Contribution)
38. Diphenylethylenediamine-Based Potent Anionophores: Transmembrane Chloride Ion Transport and Apoptosis Inducing Activities
                                            Akhtar, N.+; Saha, A.+; Kumar, V.+; Pradhan, N.; Panda, S.; Morla, S.; Kumar, S.; Manna. D.*
                                            ACS Applied Materials & Interfaces, 2018, 10 (40), 33803-33813.
                                            (+, Equal Contribution)
Patents
2. Title: Quinoline-based zinc ionophores display antimicrobial activity"
Application No: 202231073119; E-106/835/2022/KOL
Inventors: Debasis Manna, Subhasis Dey, Anjali Patel, Soumya Srimayee

1.  Title: Triazole derivatives and a method of its preparation
Granted Patent No. 391942; Application No. 201731045989; TEMP/E-1/46735/2017-KOL
Inventors: Debasis Manna, Subhankar Panda, Nirmalya Pradhan, Ashalata Roy, Sachin Kumar
Group Activities
40. pH-Regulated anion transport activities of bis(iminourea) derivatives across the cell and vesicle membrane
                                           Saha, A.+; Akhtar, N.+; Kumar, V.; Kumar, S.; Srivastava, K. H; Kumar, S.; Manna. D.*
                                            Organic & Biomolecular Chemistry, 2019,17, 5779-5788.
39. Fatty-Amine-Conjugated Cationic Bovine Serum Albumin Nanoparticles for Target-Specific Hydrophobic Drug Delivery,
                                            Saha, A.+; Pradhan, N.+; Chatterjee, S.; Singh, K. R.; Trivedi, V.; Bhattacharyya, A.; Manna. D.*
                                   ACS Applied Nano Materials, 2019, 26, 3671-3683.
                                 
41. Tuning the Solubility of the Ionophores: Glutathione-Mediated Transport of Chloride Ion across the Membranes,
                                            Akhtar, N.; Pradhan, N.; Saha, A.; Vishnu Kumar, V.; Biswas, O.; Dey, S.; Shah, M.; Kumar, S.; Manna. D.*, 
                                   Chemical Communications, 2019,55, 8482-8485.
43. Sunlight-Mediated Thiol-Ene/Yne Click Reaction: Synthesis and DNA Transfection Efficiency of New Cationic Lipids
                                            Dey, S.; Gupta, A.; Saha, A.; Pal, S.; Kumar, S.*; Manna, D.*
                                            ACS Omega, 2020, 5, 1, 735-750.
42. 4,5-Disubstituted 1,2,3-triazoles: Effective Inhibition of Indoleamine 2,3-Dioxygenase 1 Enzyme Regulates T cell Activity and Mitigates Tumor Growth
                                            Panda, S.+;Pradhan, N.+; Chatterjee, S.; Morla, S.; Saha, A.; Roy, A.; Kumar, S.; Bhattacharyya, A.*; Manna, D.*
                                            Scientific Reports, 2019, 9, 1-16 (18455).
                 
45. Chloride Ion Transport by PITENINs across the Phospholipid Bilayers of Vesicles and Cells
                                            Biswas, O.; Akhtar, N.; Vashi, Y.; Saha, A.; Kumar, V.; Pal , S.; Kumar, S.; Manna, D.*
                                            ACS Applied Bio Materials, 2020, 3(2), 935–944.
44. Stimuli-Responsive Anticancer Drug Delivery System with Inherent Antibacterial Activities
                                            Dey, S.; Patel, A.; Raina, K.; Pradhan, N.; Biswas, O.;   Rajkumar P. Thummer, P. R.*; Manna, D.*
                                            Chemical Communications, 2020, 56, 1661-1664.
49. Multi-stimuli Controlled release of Transmembrane Chloride ion Carrier from Sulfonium-linked Procarrier
                                            Das, S.; Biswas, O.; Akhtar, N.; Patel, A.; Manna, D.*
                                            Organic & Biomolecular Chemistry, 2020, 18, 9246-9252.
48. Biological Applications of Synthetic Anion Transporters
                                            Akhtar, N.; Biswas, O.; Manna, D.*
                                            Chemical Communications, 2020, 56, 14137-14153.
47. Transforming growth factor beta orchestrates PD-L1 enrichment in tumor derived exosomes and mediates CD8 T cell dysfunction regulating early phosphorylation of
                                             TCR signalome in breast cancer                                      
                                            Chatterjee, S.; Chatterjee, A.; Jana, S.; Dey, D.; Roy, H.; Das, K. M.; Alam, J.; Adhikary, A.; Chowdhury, A.; Biswas, A.; Manna, D.; Bhattacharyya, A.*
                                           Carcinogenesis, 2021, 42, 38-47.
46. Quinine-Based Semisynthetic Ion Transporters with Potential Antiproliferative Activities
                                            Akhtar, N.;  Pradhan, N.+; Barik, G., Chatterjee, S.; Ghosh, S.; Saha,  A.; Satpati, P.; Bhattacharyya, A.; Santra, M.; Manna, D.*,
                                            ACS Applied Materials & Interfaces, 2020, 12(23), 25521–25533.
50. Inhibition of Immunosuppressive Indoleamine 2,3-Dioxygenase by Targeting the Heme and Apo form
                                               Pradhan, N.; Akhtar, N.; Nath, B.; Pena-Garcia, J.; Gupta, A.; Perez-Sanchez, H.; Kumar, S.; Manna, D.*,
                                               Chemical Communications, 2021, 57, 395-398.

54. Antimicrobial Two-Dimensional Covalent Organic Nanosheets (2D-CONs) for Fast and Highly Efficient Capture and Recovery of Phosphate Ions from Water
                                                 Dey, S.+; Das, S.+; Patel, A.+; Raj, K. V.; Vanka, K.; Manna, D* (+; Equal contribution)
                                                 Journal of Materials Chemistry A, 2022, 10, 4585-4593
53. Stimuli-responsive Transmembrane Anion Transport by AIE-active Fluorescent Probe
                                                Akhtar, N.; Biswas, O.; Manna, D.*
                                                Organic & Biomolecular Chemistry, 2021, 19, 7446-7459
52. Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity              
                                                Patel, A.; Dey, S.; Shokeen, K.; M. Karpiski, M. T.; Sivaprakasam, S.; Kumar, S. ; Manna, D.*
                                                RSC Medicinal Chemistry, 2021, 12, 1005-1015
51. Photoresponsive transformation from spherical to nanotubular assemblies: anticancer drug delivery using macrocyclic cationic gemini amphiphiles                  
                                                Dey, S.; Chatterjee, S.; Patel, A.; Pradhan, N.; Srivastava, D.; Patra, N.; Bhattacharyya, A.;  Manna, D.*
                                                Chemical Communications, 2021, 57, 4646-4649

60. Transmembrane fluoride anion transport by meso-3,5-bis(trifluoromethyl)phenyl picket calix[4]pyrrole
                                                    Patra, A. K., Srimayee, S., Halder, D., Roy, A., Mukherjee, S., Kundu, S., Hossain, M., Saha, R., Lee, C.H., Manna, D.*,  Saha, I*
                                                   Chemical Communications, 2023, 59, 7407-7410               
59. Amidation reaction to derive waterborne, tolerant, and optically transparent solid slippery and superhydrophobic coatings
                                                   Kumar, S. Dhar, M. Prusty, B.M. Sarkar, D., Das, A., Manna, D., Manna, U.*
                                                    Chemical Engineering Journal, 2023, 465, 142776
58. A  small  molecule  potent  IRAK4  inhibitor  abrogates  lipopolysaccharide-1 induced macrophage inflammation in-vitro and in-vivo
                                                   Choudhary, A. S., Patra, D., Sinha, A., Mazumder, S., Pant, R., Chouhan, R., Jha, N. A., Prusty, M. B., Manna, D., Das, K. S., Tikoo, K., Pal, D., Dasgupta, S.,*
                                                   European Journal of Pharmacology, 2023, 944, 175593
57. Guanidine functionalized fluorescent sp2 carbon-conjugated covalent organic framework for sensing and capture of Pd(II) and Cr(VI) ions
                                                   Das, S., Hazarika, G., and Manna, D.*
                                                   Chemistry- A European Journal, 2023, 29, e202203595
56. Onium-and alkyl amine-decorated protein nanoparticles as antimicrobial agents and carriers of antibiotics to promote synergistic antibacterial and antibiofilm activities
                                                   Patel, A., Paul, S., Akhtar, N., Das, S., Kar, S., Bhattacharjee, S.*, and Manna, D.*
                                                   ACS Applied Nano Materials, 2022, 5, 11, 16602-16611
55. A photo-responsive fluorescent amphiphile for target-specific and image-guided drug delivery applications
                                                   Dey, S., Sen, P., Patel, A., Prusty, B.M., Ghosh, S. S.*, and Manna, D.*
                                                  Organic & Biomolecular Chemistry, 2022, 20, 7803-7813
62. Evaluation of mode of Indoleamine 2,3-dioxygenase 1 Inhibition by 4,7-dichloroquinolines
                                                    Das,M. N., Prusty, B. M., Pradhan, N., Gupta, A., Carmena Bargueno, M., Karn, R., Perez Sanchez, H.,* Kumar, S.* Manna, D*
                                                    European Journal of Medicinal Chemistry Reports, 2023, 9, 100110
61. Quinoline Thiourea-Based Zinc Ionophores with Antibacterial Activity
                                                   Dey, S., Patel, A., Haloi, N., Srimayee, S., Paul, S., Barik, G. K., Akhtar, N., Shaw, D., Hazarika, G., Prusty, B. M.,
                                                    Kumar, M., Santra, M. K., Tajkhorshid, E.*, Bhattacharjee, S.*, and Manna, D.*
                                                    Journal of Medicinal Chemistry, 2023, 66, 11078–11093
64. Leishmania LPG interacts with LRR5/LRR6 of macrophage TLR4 for parasite invasion and impairs the macrophage functions
                                                    Mazumder, S., Sinha, A., Ghosh, S., Sharma, G. C., Prusty, B. M., Manna, D., Pal, Durba., Pal, C., Dasgupta, S.*
                                                    Pathogens and Disease, 2023, 81, ftad019
63. Stimuli-responsive assembly and disassembly of anionic suprasomes with tunable antibacterial activity
                                                    Prusty, B. M., Karn, R., Patel, A., Mazumder, P., Kumar, S., Manna, D*
                                                    Chemical Communications, 2023, 59, 10624-10627
66. Imidazo[2,1-b]thiazole based indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor: Structure based design, synthesis, bio-evaluation and docking studies
                                                    Singh, R., Kumar, R., Roy, A., Behera, P. M., Atri, A. K., Kumar, K., Manna, D., Dixit, A., Patil, M. T., Kumari, R. M.,
                                                    Nimesh, S., Salunke D. B.
                                                    Bioorganic & Medicinal Chemistry Letters, 2023, 96, 129532
65. Stimuli-responsive release of active anionophore from RGD-peptide-linked proanionophore
                                                   Srimayee, S., Badajena, R. S., Akhtar, N., Kar, K. M., Dey, S., Mohapatra. P.,* Manna, D.*
                                                    Chemical Communications, 2023, 59, 12759-12762
69. A chloride-responsive molecular switch: driving ion transport and empowering antibacterial properties
                                                     Das, S., Karn, R., Kumar,  M., Srimayee, S., Manna, D.*
                                                    Organic & Biomolecular Chemistry, 2024, 22, 114-119
68.  Superhydrophobic nanosized metal–organic framework composites for the targeted removal of hydrophobic pharmaceuticals with outstanding bacterial
                                                   anti-adhesion properties
                                                    Ghosh, S., Rana, A., Patel, A., Manna, D., Biswas, S.*
                                                    Environmental Science: Nano, 2024, Advance Article
67. Sulfonium-cross-linked hyaluronic acid-based self-healing hydrogel: Stimuli-responsive drug carrier with inherent antibacterial activity to counteract
                                                    antibiotic-resistant bacteria                    
                                                    Patel, A., Goswami, S., Hazarika, G., Sivaprakasam, S., Bhattacharjee, S.*, Manna, D.*
                                                    Advanced Healthcare Materials, 2023, Advance Article