Proteins - a string of amino acids doing wonders!!!! Nature designs everything with a purpose. Proteins also fall into this regime of nature. Our research group efforts to understand the unwritten constitutional laws of nature framed for proteins. The uniqueness in sequence and structure of proteins renders them specific function. The obedients and the extremists!!!!
Some enzymes as endonuclease, RNA polymerase and nitrite reductase from Pyrococcus furiosus are active at extreme temperature close to 100 degree centigrade, while others as lipases from Candida antarctica perform best at sinking mercury levels. Pseudomonas aeruginosa lipase is functional in organic solvents as n-decane, ethyleneglycol, Dimethylsulphoxide, n-octane, n-heptane, isooctane, and cyclohexane carrying out transesterification and racemization reactions. Alakliphiles as Spirulina maxima and acidophiles as Alicyclobacillus acidocaldarius are not bothered by extremes of pH. We try to intrude into these aspects of enzymes, trying to find what can be done to emulate their function, lengthen their storage in vivo, deliver them at required destinations etc. Organisms keep working as the innumerable enzymes in them are busy performing their assigned responsibilities. Many of them serve as markers for various diseases and hence can be instrumental for disease diagnosis. The success of disease causing organisms is because of the employment of cascade of enzymes. The identification and inhibition of such targets can cure diseased state. Our research group tries to understand and address them.
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