Dr. Krishna Pada Bhabak
Assistant Professor
Department of Chemistry, Room No: CHF 007
Indian Institute of Technology Guwahati (IITG)
Guwahati-781039, Assam, India
Ph No: +91-361-258-3476(O) 4344 (Lab) 5476(R)
Fax No: +91-361-258-2349
Email: kbhabak@iitg.ac.in; kbhabak@gmail.com
Professional Experience
Apr, 2015 - Present: Assistant Professor, Department of Chemistry, Indian Institute of Technology Guwahati (IITG), Assam, India
Feb, 2013 - Apr, 2015: Assistant Professor, Department of Chemistry, Presidency University, Kolkata, India.
Nov, 2012 - Feb, 2013: Post-doctoral Researcher, University of Oxford, Oxford, United Kingdom .
Jul, 2010 - Oct, 2012: Post-doctoral Researcher (Alexander von Humboldt Fellow), Humboldt University, Berlin, Germany
Aug, 2009 - Jun, 2010: Research Associate, Indian Institute of Science, Bangalore, India
Education
Aug, 2006 - Jul, 2009: PhD, Inorganic & Physical Chemistry, Indian Institute of Science, Bangalore, India
(Supervisor: Prof. G. Mugesh).
Aug, 2003 - Apr, 2006: Masters Degree (MS) in Chemical Science, Indian Institute of Science, Bangalore, India.
Aug, 2000 - Jul, 2003: B.Sc. (Chemistry Hons.), R. K. Mission Residential College, Narendrapur, University of Calcutta, India.
Awards/Fellowships
Jan, 2013: INSPIRE Faculty Award by Department of Science and Technology (DST), India
Dec, 2010: Best Thesis Award by Eli Lilly and Company Outstanding Thesis Award 2010 in Asia.
Mar, 2010: Alexander von Humboldt Fellowship for Post-doctoral Researcher by Alexander von Humboldt Foundation, Germany
Bioorganic Chemistry Research Laboratory @ IITG
Bioorganic Chemistry Research Laboratory @ IITG
Bioorganic Chemistry Research Laboratory
My research experience is mainly in the field of Organic/Bioorganic Chemistry. Research interests in our group include the design and synthesis of organic compounds or fluorescently labeled compounds having potentials relevant to different biomedical processes that lead to various disease states such as cancer or inflammatory diseases. We undertake a number of analytical, Spectroscopic, kinetic, biochemical and biological (in vitro and cellular) assay methods/strategies to evaluate their potencies. Suitable computational approaches are adopted to further support our experimental findings as applicable.
Selected Publications
- Mahato, S. K.; Bhattacherjee, D.; Bhabak, K. P.* "Biothiol-triggered Organotrisulfide-based Self-immolative Fluorogenic Donors of Hydrogen Sulfide Enabling Lysosomal Trafficking" Chem. Commun. 2020, 56, 7769-7772.
- Bhattacherjee, D.; Sufian, A.;§ Mahato, S. K.;§ Begum, S.;§ Banerjee, K.; De, S.; Srivastava, H. K.* Bhabak, K. P.* "Trisulfides over disulfides: highly selectivesynthetic strategies, anti-proliferative activitiesand sustained H2S release profiles" Chem. Commun. 2019, 55, 13534-13537.
(§contributed equally to the work)
- Banerjee, K.; Padmavathi, G.; Bhattacherjee, D.; Saha, S.; Kunnumakkara, A. B.; Bhabak, K. P.* "Potent Anti-proliferative Activities of Organochalcogenocyanates towards Breast Cancer" Org. Biomol. Chem. 2018, 16, 8769-8782.
- Bhattacherjee, D.; Basu, C.; Bhardwaj, Q.; Mal, S.; Sahu, S.; Sur, R.; Bhabak, K. P.* "Design, Synthesis and Anti-Cancer Activities of Benzyl Analogues of Garlic-Derived Diallyl Disulfide (DADS)and the Corresponding Diselenides" ChemistrySelect, 2017, 2, 7399-7406.
- Bhattacherjee, D.; Bhabak, K. P.* "Atom based 3D-QSAR studies on 2,4-dioxopyrimidine-1-carboxamide analogs: Validation of experimental inhibitory potencies towards acid ceramidase" Eur. J. Pharm. Sci. 2016, 83, 8-18.
- Bhabak, K. P.; Hauser, A.; Redmer, S.; Banhart, S.; Heuer, D.; Arenz, C.* "Development of a Novel FRET Probe for the Real-Time Determination of Ceramidase Activity" ChemBioChem 2013, 14, 1049-1052.
(This work has been featured on the Cover Page of the Journal)
- Bhabak, K. P.; Arenz, C.*"Novel Amide- and Sulfonamide-based B-13 and D-MAPP Analogues: Effect of Aromatic Substituents on the Inhibition of Acid and Neutral Ceramidases" Bioorg. Med. Chem. 2012, 20, 6162-6170.
- Bhabak, K. P.; Bhuyan, B. J.; Mugesh, G.* "Bioinorganic and Medicinal Chemistry: Aspects of Gold(I)-Protein Complexes."
- Bhabak, K. P.; Mugesh, G.* "Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants."
(This work has been featured on the Cover Page of the Journal)
- Bhabak, K. P.; Mugesh, G.* "Antithyroid Drugs and their Analogues Protect Against Peroxynitrite-Mediated Protein Tyrosine Nitration -A Mechanistic Study." Chem. Eur. J. 2010, 16, 1175-1185.
(This work has been featured on the Cover Page of the Journal)
- Bhabak, K. P.; Mugesh, G.* "Synthesis and Structure-Activity Correlation Studies of Secondary and Tertiary Amine-based Glutathione Peroxidase Mimics." Chem. Eur. J. 2009, 15, 9846-9854.
- Bhabak, K. P.; Mugesh, G.* "A Simple and Efficient Strategy To Enhance the Antioxidant Activities of Amino-Substituted Glutathione Peroxidase Mimics." Chem. Eur. J. 2008, 14, 8640-8651.
- Bhabak, K. P.; Mugesh, G.* "Synthesis, Characterization and Antioxidant Activity of Some Ebselen Analogues."
