Ongoing Research Topics

    Artificial Skin & Wound Care

  • The statistics on rising number of traumatic injuries and chronic wounds have led to the

    increasing demand of immediate medical care and off-the-shelf availability of wound

    dressings and skin substitutes. Autografts and allografts, considered best to replace damaged

    skin often lead to greater mortality risk, prolonged hospital stay and are very expensive.

    There is a substantial need for tissue-engineered skin which can quickly restore all the

    functions of skin without further complications. We are using silk fibroin biomaterial to

    develop nanofibrous wound dressing matrices for chronic wounds and 3D scaffold for

    artificial skin graft to reduce the cost and complications of the present scenario.

    • Bone Tissue Engineering

  • Tissue engineered bone grafts are increasingly being used in clinical settings to facilitate bone

    repair. Some of the major challenges still unresolved are osseo-integration, bio-resorbability

    and long-term survivability of implant. We focus on addressing these shortcomings by

    combining the innate osteoconductivity possessed by bio-ceramics and the inherent bioactive

    properties of the North-East Indian silk varieties to develop bio-mimetic composites in

    different formats viz., 3D scaffolds, electrospun mats, nano-composites to meet the required

    clinical needs

    • Cartilage Tissue Engineering

  • Cartilage tissue engineering work at our lab focuses at repairing defects of the articulated

    surface of the joint. Tissue engineering has immense potential to revolutionize the treatment

    of damaged articular cartilage, but faces a major challenge of producing functional cartilage

    with thickness and biochemical properties comparable to native articular cartilage. Mature

    joint cartilage is avascular, aneural and alymphatic connective tissue and therefore unable to

    repair itself sufficiently when damaged. Our research delves on methods to fabricate an ideal

    silk based scaffold system that supports the growth of chondrocytes and maintains their


    • Intervertebral Disc Tissue Engineering

  • Intervertebral disc degeneration (IDD) is the major cause of lower back pain and limited

    mobility. IDD affects about 80% of the population and significantly contributes to healthcare

    expenditures. Current therapeutic treatments are only effective in symptomatic pain relief

    without restoring biomechanical function of intervertebral disc. In our lab, we are trying to

    develop silk based cost effective tissue engineered construct that can restore biochemical and

    biomechanical functions of damaged intervertebral discs.

    • Vascular Grafts

  • Cardiovascular malfunctioning is one of the prime causes of death globally. Among other

    reasons, coronary artery occlusion contributes the most. Unavailability of healthy autologous

    grafts challenges the current treatment options and demands an appropriate alternative. In

    our laboratory, we are working on developing small diameter vascular grafts using Indian

    endemic silk varieties. Our major focus is towards mimicking native like architecture and

    maintenance of functional cellular phenotype with optimal mechanical properties.

    • Cardiac Tissue Engineering

  • Incidences of myocardial infarction (MI) leading to heart failure are increasing annually. The

    infarcted tissue undergoes a myriad of changes from variations in neuro-hormonal signalling,

    invasion of fibroblast cells in the affected areas to complete ventricular remodelling. Our

    research focuses on developing a tissue engineering approach in-order to rescue heart

    functioning post MI. In order to accomplish this task we are exploring the potential of non-

    mulberry silk fibroin for developing 3D constructs which can not only provide support to the

    cardiomyocytes but also provide apt molecular cues for the cells to grow into a functional

    tissue. Our research strives to translate this construct to clinical therapy where autologous

    stem cells could be used to form the cardiac tissue.

    • Bioartificial Pancreas

  • Type 1 diabetes is a chronic disorder that occurs due to auto-immune destruction of insulin

    producing ? cells and leads to hyperglycemia in the blood, which currently affects 200

    million people all over the world. The cardinal objective of our research is development of a

    'Bio-artificial Pancreas' (BAP) for the treatment of diabetes by mimicking pancreatic like

    niche around resident cells allowing them to produce insulin overtime. This BAP is projected

    as a surrogate for the host pancreas damaged in diabetics. Our silk-based BAP devices are

    based on supply of high quality insulin producing cells for its successful clinical translation.

    • Bioartificial Liver Systems

  • Liver, one of the largest metabolic organs performs various functions like detoxification,

    synthesis and regulation. People with chronic liver diseases rely on organ transplantation,

    often associated with a number of complicacies. Bioartificial liver devices act as a bridge by

    performing some of the liver functions and helping the damaged liver to regenerate. Herein,

    we are evolving a matrix using silk protein that can be used in bioartificial liver systems.

    Works are also directed to the development of scaffolds for liver tissue engineering.

    • Sericin For Skin Care And Tissue Engineering

  • Recent focus has been directed towards exploitation of sericin (a common waste of the

    sericulture industry) for prospective applications in biomaterial domain specifically for tissue

    engineering. We are currently focusing on fabrication of skin care products based on sericin

    endowed with desirable properties like antioxidant, anti-tyrosinase and anti-lipid peroxidation

    among others. Apart from this, we are delving into the prospects of fabrication of 3D

    nanomaterials for application as nanotherapeutics/anticancer agents.

    • Nanobiotechnology & Biofluorescence

  • Nanotechnology representing the nexus of scientific innovations aims to usher in novel

    avenues of exploring materials at the nano scale for diverse applications. In this context, we

    are: a) Exploiting the prospects of electrospun nanofibrous silk fibroin mats for actuated

    delivery of cells and bioactive cargoes and interfacial tissue engineering; b) Investigating the

    biointerfacial action of bio-based carbonaceous nanoparticles for applications like bioimaging

    and drug delivery and c) Fabricating silk fibrous nanocomposite for environmental

    remediation with special impetus on arsenic mitigation.Furthermore, we are delving into the

    intrinsic fluorescence of silk proteins, isolated from silk worms, endemic to North East India

    for prospective applications in biomaterial science.