Laboratory for

Stem Cell Engineering and Regenerative Medicine



Welcome to SCERM LAB

If interested, please read our most recent review article titled "An Insight into DNA-free Reprogramming Approaches to Generate Integration-free Induced Pluripotent Stem Cells for Prospective Biomedical Applications." published in Stem Cell Rev and Rep.

Research Areas

  • Generation of transgene-free induced Pluripotent Stem Cells (iPSCs) using non-integrative approaches.
  • Understanding the molecular mechanisms of cell reprogramming.
  • Enhancing the efficiency and the kinetics of cell reprogramming.
  • Generation of functional cardiomyocytes from either iPSCs or by direct reprogramming of somatic cells using integrative and non-integrative approaches.
  • Generation of functional insulin producing β-cells from either iPSCs or by direct reprogramming of somatic cells using integrative and non-integrative approaches.
  • Design and development of novel non-integrating vectors for iPSC generation.
  • Investigating the role of core stem cell-specific transcription factors governing stem cell self-renewal, pluripotency and differentiation.
  • Elucidating the epigenetic mechanisms governing stem cell self-renewal, pluripotency and differentiation.
  • Identifying the crucial differences between normal stem cells vs cancer stem cells.
  • Genome editing in pluripotent stem cells.
  • Understanding stem cell heterogeneity.