My Research

Publications

2022
S Kalita, S Kalita, AH Kawa, S Shill, A Gupta, S Kumar, B Mandal. Copper Chelating Cyclic Peptidomimetic Inhibits A? Fibrillogenesis. RSC Med. Chem., 2022
2022
A proteolytic functional amyloid digests pathogenic amyloids. J. Mater. Chem. B, 2022, 10, 4216-4225
2022
G Dolai, RS Giri, B Mandal. Versatility in self-assembly and morphology of non-coded anthranilic acid and phenylglycine based dipeptide stereoisomers. CrystEngComm, 2022, 24, 3778-3790
2022
RS Giri, B Mandal. Supramolecular helical self-assembly of small peptides. CrystEngComm. 2022, 24, 10-32
2021
Dolai, G.; Roy, S.; Sen, S.; Giri, R. S.; Mandal, B. Crystal structure of 1-(2,4,6-trichlorobenzoyloxy) benzotriazole (TCB-OBt): observation of uncommon intermolecular oxygen–oxygen interaction and synthetic application in amidation. New J. Chem. 2021, 45, 19804-19811
2021
Gobinda Dolai, Rajat S Giri, Bhubaneswar Mandal. Protecting Group-Directed Diversity in the Morphology of Self-Assembled Ant-Aib Dipeptides: Garland-Like Architecture and Nanovesicle Formation. ACS Appl. Bio Mater. 2021, 4, 8343-8355
2021
Tapasi Kalita, Bhubaneswar Mandal. One?Pot Synthesis of Amide, Dipeptide, Ester, and Hydroxamate Using Oxyma and Thionyl Chloride (SOCl2). ChemistrySelect. 2021, 6, 12281-12287
2021
Tapasi Kalita, Dharm Dev, Sandip Mondal, Rajat Subhra Giri, Bhubaneswar Mandal*. 'Ethyl-2-Cyano-2-(2-Nitrophenylsulfonyloximino)Acetate(ortho-NosylOXY) Mediated One-Pot Racemization Free Synthesis of Ureas, Carbamates, and Thiocarbamates via Curtius Rearrangement." Asian Journal of Organic Chemistry. 2021, 6, 1523-1529
2021
Gobinda Dolai, Rajat Subhra Giri, Sayanta Roy, Bhubaneswar Mandal*. 'Crystal structure and supramolecular arrangement of heterochiral tripeptides' Peptide Science. 2021, e24229
2021
Ashim Paul, Sourav Kumar, Sujan Kalita, Sourav Kalita, Dibakar Sarkar, Anirban Bhunia, Anupam Bandyopadhyay, Amal Chandra Mondal, Bhubaneswar Mandal*. 'An explicitly designed paratope of Amyloid-? prevents neuronal apoptosis in vitro and hippocampal damage in rat brain' Chemical Science. 2021, 12, 2853-2862
2021
Sourav Kalita, Sujan Kalita, Ashim Paul, Manisha Shah, Sachin Kumar, Bhubaneswar Mandal*. 'Site-specific single point mutation by anthranilic acid in hIAPP 8–37 enhances anti-amyloidogenic activity' RSC Chemical Biology. 2021, 2, 266-273
2020
Dharm Dev , Tapasi Kalita , Tanmay Mondal , Bhubaneswar Mandal*. 'Ethyl 2?Cyano?2?(2?nitrobenzenesulfonyloxyimino) Acetate (ortho?NosylOXY)?Mediated Double Beckmann Rearrangement of Ketoximes under Microwave Irradiation: A Mechanistic Perception.' Advanced synthesis and catalysis. 2020. DOI: https://doi.org/10.1002/adsc.202001416
2020
Tapasi Kalita , Dr. Srinivasa Rao Manne , Prof. Bhubaneswar Mandal* 'Ethyl?2?cyano?2?(2?nitrophenylsulfonyloximino)acetate (ortho? NosylOXY) Mediated Acetalization and Thioacetalization of Aldehydes' Chemistryselect. 2020, 5, 12298-12301
2020
Sayanta Roy, Rajat Subhra Giri, Gobinda Dolai, Bhubaneswar Mandal*. 'Role of Side-Chain and Chirality of the Amino acids on the Supramolecular Assemblies of Dipeptides' Journal of Molecular Structure. 2020. DOI: https://doi.org/10.1016/j.molstruc.2020.128877
2020
Rajat Subhra Giri, Saikat Pal, Sayanta Roy, Gobinda Dolai, Srinivasa Rao Manne, Sandip Paul Bhubaneswar Mandal ' Nanostructures from protected L/L and D/L amino acid containing dipeptides' Pept Sci. 2020;e24176. DOI: https://doi.org/10.1002/pep2.24176
2020
Sujan Kalita, Sourav Kalita, Ashim Paul, Amar Sarkar, and Bhubaneswar Mandal*. 'Peptidomimetics prepared by tail-to-side chain one component peptide stapling inhibit Alzheimers amyloid-? fibrillogenesis' Chemical Science. 2020, 11 (16), 4171-4179
2020
Rajat S. Giri, Sayanta Roy, Gobinda Dolai, Srinivasa R. Manne, and Bhubaneswar Mandal*. 'FeCl3-Mediated Boc Deprotection: Mild Facile Boc-Chemistry in Solution and on Resin' ChemistrySelect. 2020, 5, 2050–2056
2020
Tanmay Mondal and Bhubaneswar Mandal*. 'Total degradation of extracellular amyloids by miniature artificial proteases' ChemComm. 2020, 56, 2348-2351. DOI: 10.1039/c9cc09409a. (Invited for a feature back cover of ChemComm)
2019
Rajat Subhra Giri and Bhubaneswar Mandal*. 'Formation of Supramolecular Single and Double Helix-like Structures by Designed Tripeptides' CrystEngComm. 2019, 21, 5618-5625. DOI: 10.1039/C9CE01168D . (Invited for a feature back cover of crystEngComm)
2019
Tanmay Mondal and Bhubaneswar Mandal*. "Engineered peptidic constructs metabolize amyloid ? by Self-assembly-driven reactions" ChemComm. 2019, 55, 4933-4936 . (Invited for a feature back cover of ChemComm)
2019
Sourav Kumar, Saurabh Srivastav, Mahino Fatima, Rajat Subhra Giri, Bhubaneswar Mandal and Amal Chandra Mondal*'A Synthetic Pro-Drug Peptide Reverses Amyloid-?-Induced Toxicity in the Rat Model of Alzheimers Disease.'J Alzheimers Dis. 2019;69(2):499-512
2019
Srinivasa Rao Manne, Jyoti Chandra, and Bhubaneswar Mandal* 'Synthesis of o-Nitroarylamines via Ipso Nucleophilic Substitution of Sulfonic Acids' Org. Lett. 2019, 21, 636?639
2019
Rajat Subhra Giri and Bhubaneswar Mandal,'Unique crystallographic signatures of Boc-Gly-Phe-Phe-OMe and Boc-Gly-Phg-Phe-OMe and their self-association'CrystEngComm. 2019, 21, 236–243 .(Invited for a feature back cover of crystEngComm)
2019
Bhisma Narayan Ratha, Rajiv K. Kar, Sujan Kalita, Sourav Kalita, Sreya Raha, Achintya Singha, Kanchan Garai, Bhubaneswar Mandal, Anirban Bhunia,'Sequence specificity of amylin-insulin interaction: a fragment-based insulin fibrillation inhibition study' BBA - Proteins and Proteomics. 1867 (2019) 405–415
2018
Jyoti Chandra, Srinivasa Rao Manne, Sandip Mondal, Bhubaneswar Mandal*, "(E)-Ethyl-2-cyano-2-(((2, 4, 6-trichlorobenzoyl) oxy) imino) acetate: A Modified Yamaguchi Reagent for Enantioselective Esterification, Thioesterification, Amidation, and Peptide Synthesis", ACS Omega. 2018, 3(6), 6120-6133
2018
Rajat Subhra Giri, Bhubaneswar Mandal*, "Boc-Val-Val-OMe (A?39-40) and Boc-Ile-Ala-OMe (A?41-42) crystallize in parallel ?-sheet arrangement but generate different morphology", CrystEngComm. 2018, 20, 4441-4448
2018
Srinivasa Rao Manne, Jyoti Chandra, Rajat Subhra Giri, Tapasi Kalita, and Bhubaneswar Mandal* Synthesis of ??Amino Alcohols Using Ethyl 2?Cyano?2?(2?nitrobenzenesulfonyloxyimino)acetate (o?NosylOXY),ChemistrySelect. 2018, 3, 992–996
2018
Ashim Paul, Sourav kumar, Sourav Kalita, Anup Kumar Ghosh, Amal Chandra Mondal* and Bhubaneswar Mandal*, "A Peptide Based Pro-Drug Disrupts Alzheimers Amyloid into Non-Toxic Species and Reduces A? Induced Toxicity in vitro", International Journal of Peptide Research and Therapeutics. 2018, 24(1), 201–211
2017
Rajat Subhra Giri, Srinivasa Rao Manne, Gobinda Dolai, Ashim Paul, Tapasi Kalita, Bhubaneswar Mandal*, “FeCl3-Mediated Side Chain Modification of Aspartic Acid-and Glutamic Acid-Containing Peptides on a Solid Support” ACS Omega. 2017, 2, 6586?6597
2017
Jyoti Chandra, Rohit Chaudhuri, Srinivasa Rao Manne, Sandip Mondal, Bhubaneswar Mandal*, “Direct Synthesis of Sulphonates of Alcohol, Oxyma-O-sulphonates and Oxime-O-sulphonates under Microwave Irradiation”, ChemistrySelect. 2017, 2, 8471-8477
2017
Sourav Kumar, Ashim Paul, Sourav Kalita, Awanish Kumar, Saurabh Srivastav, Somoday Hazra, Anup Kumar Ghosh, Bhubaneswar Mandal, Amal Chandra Mondal, "A Peptide Based Pro-Drug Ameliorates Amyloid-? Induced Neuronal Apoptosis in in vitro SH-SY5Y cells", Current Alzheimer Research. 2017, 14(12), 1293-1304
2017
Saumya Prasad, Imon Mandal, Shubham Singh, Ashim Paul, Bhubaneswar Mandal, Ravindra Venkatramani, Rajaram Swaminathan, “Near UV-Visible Electronic Absorption Originating from Charged Amino Acids in a Monomeric Protein”, Chem. Sci., 2017,8, 5416-5433
2017
Ashim Paul, Sourav Kalita, Sujan Kalita, Piruthivi Sukumar and Bhubaneswar Mandal*, "Disaggregation of Amylin Aggregate by Novel Conformationally Restricted Aminobenzoic Acid containing ?/? and ?/? Hybrid Peptidomimetics", Scientific Reports (Nature Publishing Group) :7, 40095
2017
Sourav kumar, Ashim Paul, Sourav Kalita, Anup Kumar Ghosh, Amal Chandra Mondal* and Bhubaneswar Mandal*, "Protective effects of ?-sheet breaker ?/? hybrid peptide against Amyloid ? induced neuronal apoptosis in vitro", Chemical Biology and Drug Design. 2017 Jun;89(6):888-900
2017
Srinivasa Rao Manne, Kishore Thalluri, Rajat Subhra Giri, Jyoti Chandra and Bhubaneswar Mandal*, "Ethyl 2-(tert-Butoxycarbonyloxyimino)-2-cyanoacetate (Boc-Oxyma): An Efficient Reagent for the Racemization Free Synthesis of Ureas, Carbamates and Thiocarbamates via Lossen Rearrangement" Advanced Synthesis and Catalysis. 2017, 359, (1), 168–176
2016
Sourav Kumar, Ashim Paul, Sourav Kalita, Anup Kumar Ghosh, Bhubaneswar Mandal, Amal Chandra Mondal, "Protective effects of ??sheet breaker ?/??hybrid peptide against amyloid ??induced neuronal apoptosis in vitro"
2016
Bhanita Sharma, Sourav Kalita, Ashim Paul, Bhubaneswar Mandal and Sandip Paul*, "The role of caffeine as an inhibitor in the aggregation of amyloid forming peptides: a unified molecular dynamics simulation and experimental study" RSC Advances. 2016, 6, 78548–78558
2016
Lian Gelis*, Nikolina Jovancevic, Sophie Veitinger, Bhubaneswar Mandal, Hans-Dieter Arndt, Eva M. Neuhaus, and Hanns Hatt, "Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes", The Journal of Biological Chemistry, THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2016, 291 (34), 17772–17786
2016
Dharm Dev, Jyoti Chandra, Nani Babu Palakurthy, Kishore Thalluri, Tapasi Kalita and Bhubaneswar Mandal*, "Benzoxazole and Benzothiazole Synthesis from Carboxylic Acid in Solution and on Resin by Ethyl 2-cyano-2-(2-nitro-benzenesulfonyloxyimino) acetate and para-Toluenesulfonic Acid", Asian Journal of Organic Chemistry. DOI: 10.1002/ajoc.201500527
2016
Saumya Prasad, Imon Mandal, Ashim Paul, Bhubaneswar Mandal, Ravindra Venkatramani, Rajaram Swaminathan, “Investigation of Novel Spectroscopic Features in the Near Ultraviolet Region Arising from Non-Aromatic Amino Acids in Peptides and Proteins”, BIOPHYSICAL JOURNAL. 2016, 110 (3), 489A-489A
2016
Ashim Paul, Bhanita Sharma, Tanmay Mondal, Kishore Thalluri, Sandip Paul and Bhubaneswar Mandal*, "Amyloid ? Derived Switch-Peptides as a Tool for Investigation of Early Events of Aggregation: A Combined Experimental and Theoretical Approach", Med. Chem. Commun., 2016, 7, 311-316
2015
Bhubaneswar Mandal*, "Novel and innovative strategies for peptide based drug design against Alzheimers disease", J Pharma Care Health Sys. 2015, 2 (5), 34
2015
Srinivasa Rao Manne, Kishore Thalluri, Rajat Subhra Giri, Ashim Paul, and Bhubaneswar Mandal*, "Racemization free longer N-terminal peptide hydroxamate synthesis on solid support using ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate" Tetrahedron Letters. 2015, 56 (44), 6108-6111
2015
Kirtikumar B. Jadhav, Roman J. Lichtenecker, Anke Bullach, Bhubaneswar Mandal, and Hans-Dieter Arndt*, "Dynamic combinatorial enrichment of polyconformational D-/L-peptide dimers" Chemistry - A European Journal, 2015. 21 (15), 5898–5908. Highlighted as cover page and Hot Paper
2015
Ashim Paul, Krishna Chaitanya Nadimpally, Tanmay Mondal, Kishore Thalluri, and Bhubaneswar Mandal*, "Inhibition of Alzheimer’s Amyloid-? Peptide Aggregation and its Disruption by a Conformationally Restricted ?/? Hybrid Peptide" Chemical Communications. 2015, 51, 2245-2248
2014
Kishore Thalluri, Ashim Paul, Srinivasa Rao Manne, Dharm Dev, and Bhubaneswar Mandal*, "Microwave Assisted Chemoselective Organocatalytic Peptide Alcohol Synthesis from C-terminal Amide" RSC Advances. 2014, 4 (88), 47841 - 47847
2014
(Book Chapter) Kishore Thalluri, Dharm Dev, Nani Babu Palakurthy, Srinivasa Rao Manne, Jyoti Chandra and Bhubaneswar Mandal*, "The Coupling Reagents the World in Need Indeed", in Proceedings of International Conference on New Dimensions in Chemistry & Chemical Technologies ? Applications in Pharma Industry, NDCT-2014, 23th-25th June, 2014, JNTU Hyderabad. Prof. K. Mukkanti (Editor-in-Chief), Spectrum Publications, Hyderabad-500038, A. P. India. (ISBN 978-93-82829-90-4) 2014, p 348-351
2014
Dharm Dev, Nani Babu Palakurthy, Kishore Thalluri, Jyoti Chandra, and Bhubaneswar Mandal*, "Ethyl 2-cyano-2-(2-nitrobenzenesulfonyloxyimino)acetate (o-NosylOXY): A Recyclable Coupling Reagent for Racemization free Synthesis of Peptide, Amide, Hydroxamate and Ester" The Journal of Organic Chemistry. 2014, 79 (12), 5420–5431
2014
Kishore Thalluri, Srinivasa Rao Manne, Dharm Dev and Bhubaneswar Mandal*, "Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate (4-NBsOXY) Mediated Lossen Rearragement: Single Pot Racemization free Synthesis of Hydroxamic Acids and Ureas from Carboxylic Acids" The Journal of Organic Chemistry. 2014, 79 (9), 3765–3775
2014
Krishna Chaitanya Nadimpally, Ashim Paul and Bhubaneswar Mandal*, "Reversal of aggregation using ? breaker dipeptide containing peptides: Application to A?(1-40) self assembly and its inhibition" ACS Chemical Neuroscience. 2014, 5 (5), 400–408
2014
Nani Babu Palakurthy, Dharm Dev, Sonali Paikaray, Susmitnarayan Chaudhury, and Bhubaneswar Mandal*, "Synthesis of O-Benzyl hydroxamates Employing the Sulfonate Esters of N-Hydroxybenzotriazole" RSC Advances. 2014, 4 (16), 7952 - 7958
2014
Abhijit Saha, Krishna Chaitanya Nadimpally, Ashim Paul, Sourav Kalita and Bhubaneswar Mandal*, "Phenolic ester mediated oligopeptide synthesis promoted by HOBt" Protein and Peptide Letters. 2014, 21 (2), 188-193
2013
Nadimpally Krishna Chaitanya, Ashim Paul, Abhijit Saha and Bhubaneswar Mandal*, "Modulation of Aggregation Propensity of A?38 by Site Specific Multiple Proline Substitution" International Journal of Peptide Research and Therapeutics. 2013, 19, 365-371
2013
Dharm Dev, Nani Babu Palakurthy, Nitesh Kumar and Bhubaneswar Mandal*, "An unexpected involvement of ethyl-2-cyano-2-(hydroxyimino) acetate cleaved product in the promotion of the synthesis of nitriles from aldoximes: A mechanistic perception"Tetrahedron Lett. 2013, 4397-4400
2013
Nani Babu Palakurthy, Dharm Dev, Shubhasmin Rana, Krishna Chaitanya Nadimpally and Bhubaneswar Mandal*, "Sulfonamide Synthesis via Oxyma-O-sulfonates – Compatibility to Acid Sensitive Groups and Solid-Phase Peptide Synthesis" Eur. J. Org. Chem. 2013, 2627–2633
2013
Kishore Thalluri, Krishna Chaitanya Nadimpally, Maharishi Parasar Chakravarty, Ashim Paul and Bhubaneswar Mandal*; "Ethyl 2-(tert-Butoxycarbonyloxyimino)-2-Cyanoacetate (Boc-Oxyma) as Coupling Reagent for Racemization free Esterification, Thioesterification, Amidation and Peptide Synthesis" Advanced Synthesis and Catalysis. 2013, 355, 448-462
2012
Kishore Thalluri, Krishna Chaitanya Nadimpally, Ashim Paul and Bhubaneswar Mandal*; "Waste reduction in amide synthesis by a continuous method based on recycling of the reaction mixture" RSC Advances. 2012, 2, 6838–6845
2011
Nani Babu Palakurthy and Bhubaneswar Mandal*; "Sulfonamide synthesis using N-hydroxybenzotriazole sulfonate: an alternative to pentafluorophenyl (PFP) and trichlorophenyl (TCP) esters of sulfonic acids" Tetrahedron Lett. 2011, 52, 7132-7134
2011
Krishna Chaitanya Nadimpally, Kishore Thalluri, Nani Babu Palakurthy, Abhijit Saha and Bhubaneswar Mandal*; "Catalyst and solvent free amidation of inactiveesters of N-protected amino acids" Tetrahedron Lett. 2011, 52, 2579-2582
2008
Marie-Stephanie Camus, Sonia Dos Santos, Arunan Chandravarkar, Bhubaneswar Mandal, Adrian W. Schmid, Gabriele Tuchscherer, Manfred Mutter* and Hilal A. Lashuel*; "Switch-Peptides: Design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents" ChemBioChem. 2008, 9, 2104-2112
2006
Manfred Mutter*, Jeremy Berard, Marie-Stephanie Camus, Gabriele Tuchscherer, Arunan Chandravarkar, Bhubaneswar Mandal, Sonia Dos Santos, Lydiane Saucede, Eric Grouzmann, Karine Murat, Richard Mimna; "Switch-peptides as folding precursors in amyloid fibrillogenesis" Peptide science. 2006, 43 (LCBP-ARTICLE-2007-003), 30-31
2006
(Book Chapter) Sonia Dos Santos, Arunan Chandravarkar, Bhubaneswar mandal, Karine Murat, Lydiane Saucede, Marie-Stephanie Camus, Gabriele Tuchscherer and Manfred Mutter*; "Switch on Amyloid beta Peptide Self-Assembly by Enzyme-Triggered Acyl Migration", in Understanding Biology using Peptides, Blondelle Sylvie E. (Editor), Springer, (ISBN 978-0-387-26575) 2006, chapter 13, p 56-58
2006
Lydiane Saucede, Sonia Dos Santos, Arunan Chandravarkar, Bhubaneswar Mandal, Richard Mimna, Karine Murat, Marie-Stephanie Camus, Jeremy Berard, Eric Grouzmann, Marc Adrian, Jacques Dubochet, John Lopez, Hilal Lashuel, Gabriele Tuchscherer and Manfred Mutter*; "Switch-peptides: From conformational studies to Alzheimer’s disease" Chimia. 2006, 60, 199-202
2005
Sonia Dos Santos, Arunan Chandravarkar, Bhubaneswar mandal, Richard Mimna. Karine Murat, Marie-Stephanie Camus, Lydiane Saucede, Gabriele truscherer and manfred mutter*; " Switch on amyloid beta peptide self-assembly by enzyme triggered acyl migration" Peptide Science. 2005, 80, 568-568
2005
Sonia Dos Santos, Arunan Chandravarkar, Bhubaneswar mandal, Richard Mimna. Karine Murat, Lydiane Saucede, Patrica tella, Gabriele Truscherer and Manfred mutter*; " Switch-peptide: Controlling self assembly of amyloid beta-derived peptides in vitro by consecutive triggering of acyl migration" J. Am. chem. Soc. 2005. 127, 11888-11889
2004
Arunan Chandravarkar, Bhubaneswar mandal, Sonia Dos Santos, Luc Patiny, Gabriele Tuchscherer, Manfred mutter*; "Switch-peptides: ISN induction of conformational transitions relevant in degenerative diseases" J. Pep. Sc. 2004, 10, 100-100
2004
Manfred Mutter*, Arunan Chandravarkar, Christine Boyat, John Lopez, Sonia Dos Santos, Bhubaneswar Mandal, Richard Mimna, Karine Murat, Luc Patiny, Lydiane Saucede and Gabriele Tuchscherer; "Switch-peptides in statu nascendi: induction of conformational transitions relevant to degenerative diseases" Angew. Chem. Int. Ed. 2004, 43, 4172-4178. "Switch-Peptide in statu nascendi: Induktion von Konformationsübergängen und deren Bedeutung in degenerativen Erkrankungen" Angewandte Chemie 2004, 116 (32), 4267-4273
2004
Arunan Chandravarkar, Bhubaneswar Mandal, Sonia Dos Santos, Gabriele Tuchscherer and Manfred Mutter*; "Switch-peptides: ISN-nucleation and disruption of secondary structures relevant in degenerative diseases." Peptides, 2004, 52
2001
Damiano Banfi, Bhubaneswar Mandal, Manfred Mutter* and Luc Patiny; "Evolutionary principles for generating protein mimetics: Directed assembly of peptide loops on topological templates" Acta Biochim. Pol., 2001, 48, 1105-1107
2000
Surajit Sinha, Bhubaneswar Mandal and Srinivasan Chandrasekaran*; "Synthesis of ethyl arylacetates by means of Friedel-Crafts reactions of aromatic compounds with ethyl ?-chloro-?-(ethylthio)acetate catalyzed by ytterbium triflate" Tetrahedron Lett.2000, 41, 9109-9112. (Highlighted in ChemInform, Volume 32, Issue 8, February 20, 2001. Article first published online: 30 MAY 2010; DOI: 10.1002/chin.200108122.)
2000
Surajit Sinha, Bhubaneswar Mandal and Srinivasan Chandrasekaran*; "Selective para metalation of unprotected 3-methoxy and 3,5-dimethoxy benzoic acids with n-butyllithium-potassium tert-butoxide (LIC-KOR): synthesis of 3,5-dimethoxy-4-methyl benzoic acid" Tetrahedron Lett. 2000, 41, 3157-3160. (Highlighted in ChemInform, Volume 31, Issue 36, September 5, 2000. Article first published online: 3 JUN 2010; DOI: 10.1002/chin.200036085.)

Patents

23.01.2019

Indian Patent Application (complete specifications), filed on 23.01.2019, Title: “Design and Development of Functioal Mimics of ?-Secretase and their Application in Drug Design against Amyloidoses” . Application No. 201931002772, Inventors: Dr. Bhubaneswar Mandal and Mr. Tanmay Mondal

14.12.2017

Indian Patent Application (complete specifications), filed on 14.12.2017, Title: “A NOVEL COUPLING REAGENT FOR ESTERIFICATION, THIOESTERIFICATION, AMIDATION AND PEPTIDE SYNTHESIS” . Application No. 201731045011, Inventors: Dr. Bhubaneswar Mandal, Ms. Jyoti Chandra, Mr. Srinivasa Rao Manne and Mr. Sandip Mondal

9th May, 2017

Indian patent application (complete specifications), filed on the 9th May, 2017; Title: “A METHOD FOR PREPARTION OF SULPHONATES OF ALCOHOL, OXIME-O-SULPHONATES AND THEIR DERIVATIVES”; Application No. 201731016281; Inventors: Dr. Bhubaneswar Mandal and Ms. Jyoti Chandra. Granted on 31.07.2019, Patent No. 317283

26th May, 2016

Indian patent application (complete specifications), filed on the 26th May, 2016; Title: TITLE: “?-SHEET BREAKER PEPTIDES FOR DRUG DESIGN AGAINST DIABETES TYPE-2”; Application No. 201631018104; Inventors: Dr. Bhubaneswar Mandal and Mr. Ashim Paul. Granted on 24.03.2021, Patent No. 362950

17th September, 2015

Indian patent application (complete specifications), filed on the 17th September, 2015; Title: Beta Sheet Breaker Peptides for Anti-Alzheimer Drug Design; Application No. E-2/1727/2015/KOL; Inventors: Dr. Bhubaneswar Mandal and Mr. Ashim Paul. A provisional application was filed on the 26th September, 2014; Application No. 997/KOL/2014

Sponsored Projects

---

Title: Tailor Made Peptidomimetics Designing Against Human Islet Amyloid Polypeptide (hIAPP) Aggregation: A Therapeutic Approach Associated with Type-2 Diabetes. approved, fund yet to come ; Funding agency: DBT; Amount:

---

Title: Peptidomimetic/Peptide inhibitor design and synthesis against sEGFR to treat lung cancer -[ 28090 ]; Funding agency: DBT; Amount: ; Status: submitted

---

Title: Beta breaker di-peptides: development of a novel approach for amyloid disruption, phase II: At the quest of lead; Funding agency: BRNS; Amount: 25 Lakhs; Status: submitted

Since February 2017

Title: Effect of naturally occurring as well as synthetic cyclic molecules on inhibition of beta amyloid aggregation in vivo and in vitro; Funding agency: DBT (twinning program); Amount: 72 Lakhs; Status: Ongoing ; Co-Investigator: Dr. Amal Chandra Mondal, JNU, New DelhI

Since October, 2016

Title: Diptheria toxin derived peptides for possible therapeutic uses; Funding agency: DST; Amount: 47 Lakhs; Status: Ongoing ; PI: Dr. Biplab Bose, BSBE, IITG ; Co-PI: Dr. Bhubaneswar Mandal, CHEM, IITG

---

Title: Arresting pre fibriller aggregates of Alzheimer’s amyloid by synthetic antibodies; Funding agency: DBT (twinning program); Amount: 56 Lakhs; Status: Completed ; Co-Investigator: Dr. Amal Chandra Mondal, Raja Peary Mohan College, Uttarpara, Hooghly (W.B.)

April, 2009 – April, 2012

Title: Beta breaker di-peptides: development of a novel approach for amyloid disruption; Funding agency: BRNS (Young Scientist Research Award); Amount: 17 Lakhs; Status: Completed

Sep, 2008 – Sep, 2010

Title: A new, cost effective and green improvement of solid phase peptide synthesis; Funding agency: IITG (start up grant); Amount: 5 Lakhs; Status: Completed

March, 2009 – March, 2012

Title: Synthesis and biological evaluation of a novel class of multi-target-directed ligands as potential leads against amyloid diseases; Funding agency: DST (FAST TRACK); Amount: 19 Lakhs; Status: Completed