Department
              of
          Biosciences and Bioengineering
Indian Institute of Technology Guwahati

 

Contact Us:

Department of Biosciences & Bioengineering
Indian Institute of Technology Guwahati
Guwahati 781039

Telephone:
(0361) 258-2250
Fax: (0361) 258-2249
E-mail: biooff@iitg.ernet.in

 

Shirisha Nagotu, PhD

Assistant Professor 

CONTACT

Dr. Shirisha Nagotu
Assistant Professor
Department of Biosciences and Bioengineering
Indian Institute of Technology Guwahati
Guwahati 781039, Assam, India

Email - snagotu@iitg.ernet.in

Phone (Office): +91-361-2583209
Fax: +91-361-258-2249 

ACADEMIC QUALIFICATIONS

  • PhD, 2010 - Molecular Cell Biology, University of Groningen, Groningen, the Netherlands (Mentor - Prof. Ida van der Klei and Prof. Marten Veenhuis)

  • M.Sc Biotechnology, 2005 - University of Essex, Colchester, UK

  • B.Sc Agriculture, 2003 - Acharya N. G. Ranga Agricultural University, Hyderabad, India

PROFESSIONAL EXPERIENCE

  • Assistant Professor - Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Guwahati (IITG), Guwahati, Assam, India (July 2015 onwards).

  • Postdoctoral researcher - Membrane Biochemistry, LIMES institute, University of Bonn, Germany (2012-2013, Mentor -  Prof. Thorsten Lang)

  • Postdoctoral researcher - Systems Biochemistry, Ruhr University of Bochum, Bochum, Germany (2010-2012, Mentor - Prof. Ralf Erdmann) 

RESEARCH INTERESTS

  • Organelle biology and Inter-organelle communication

  • Cellular Ageing

  • Membrane fission and fusion 

GRANTS AND AWARDS

  1. Alexander von Humboldt Postdoctoral fellowship, Ruhr University of Bochum, Bochum, Germany 2010–2011.

  2. EMBO-Welcome trust travel grant to attend the EMBO-Welcome trust-DBT alliancemeeting in Barcelona in August 2010.

  3. American Society of Cell Biology (ASCB) Travel Grant to attend the annual meeting in San Francisco in December 2008.

  4. FEBS travel grant to attend the FEBS advanced lecture course in Maratea (Italy) in March 2007.

  5. Ubbo–Emmius PhD scholarship, University of Groningen, Groningen, The Netherlands 2005–2009.

LIST OF PUBLICATIONS  

  1. Banerjee R, Kumar A, Satpati P and Nagotu S "Mimicking human Drp1 disease-causing mutations in yeast Dnm1 reveals altered mitochondrial dynamics", Mitochondrion (2021) https://doi.org/10.1016/j.mito.2021.06.009

  2. Glingston, S., Yadav, J., Rajpoot, J., Joshi, N and Nagotu, S "Contribution of yeast models to virus research", Applied Microbiology and Biotechnology (2021) https://doi.org/10.1007/s00253-021-11331-w

  3. Glingston, S., Rajpoot, J., Deori, N.M., Deb, R., Kumar S and Nagotu S. Characterization of nucleocapsid and matrix proteins of Newcastle disease virus in yeast. 3 Biotech 11, 65 (2021). https://doi.org/10.1007/s13205-020-02624-

  4. Deb, R., Joshi, N., Nagotu, S (2021). Peroxisomes of the Brain: Distribution, functions and associated diseases. Neurotoxicity Research DOI:10.1007/s12640-020-00323-9

  5. Narayan, G., Sundaravadivelu, P. K., Agrawal, A., Gogoi, R., Nagotu, S., & Thummer, R. P. (2021). Soluble expression, purification, and secondary structure determination of human PDX1 transcription factor. Protein Expression and Purification, 105807.

  6. Pathak, S., Deori, N., Sharma, A., Nagotu, S., & Kale, A. (2020). In vitro, in vivo and in silico rationale for the muscle loss due to therapeutic drugs used in the treatment of Mycobacterium tuberculosis infection. Journal of Biomolecular Structure and Dynamics, 1-17. (IF: 3.2) 

  7. Joshi N, Atchaya SR, Nagotu S (2020) Chaperones and Proteostasis: Role in Parkinson's Disease. Diseases:8(2):E24. doi: 10.3390/diseases8020024.

  8. Pathak S, Tripathi S, Deori N, Ahmad B, Verma H, Lokhande R, Nagotu S, Kale A (2020) Effect of Tetracycline family of antibiotics on actin aggregation, resulting in the formation of Hirano bodies responsible for neuropathological disorders. Journal of Biomolecular Structure & Dynamics DOI: 10.1080/07391102.2020.1717629

  9. Banerjee R, Joshi N, Nagotu S (2019) Cell organelles and yeast longevity: an intertwined regulation. Curr Genet. 2019 doi: 10.1007/s00294-019-01035-0

  10. Banerjee R, Deb R, Roy K, Chatterjee S, Nagotu S (2018) Uptake and intracellular fate of nona-arginine peptide in yeast. Peptide Science: doi.org/10.1002/pep2.24101

  11. Deori NM, Deb R, Banerjee R, Nagotu S$. (2018) Yeast: A Multifaceted Eukaryotic Microbe and Its Biotechnological Applications. In book: Advances in Microbial Biotechnology Current Trends and Future Prospects. Publisher: APPLE ACADEMIC PRESS

  12. Glingston RS, Deb R, Kumar S, Nagotu S$. (2018) Organelle dynamics and viral infections: at cross roads. Microbes Infect; doi:10.1016/j.micinf.2018.06.002.

  13. Deori NM, Kale A, Maurya PK, Nagotu S$. (2018) Peroxisomes: role in cellular ageing and age related disorders. Biogerontology; doi: 10.1007/s10522-018-9761-9.

  14. Deb R, Nagotu S$. (2017) Versatility of peroxisomes: An evolving concept. Tissue and Cell; http://dx.doi.org/10.1016/j.tice.2017.03.002

  15. Maurya PK, Kumar P, Nagotu S, Chand S, Chandra P. (2016) Multi-target detection of oxidative stress biomarkers in quercetin and myricetin treated human red blood cells. RSC Advances 6 (58): 53195-53202

  16. Nagotu S, Kalel VC, Platta H, Erdmann R. (2012) Molecular basis of peroxisomal biogenesis disorders caused by defects in peroxisomal matrix protein import. Biochim Biophys Acta – Molecular Basis of Disease; 1822: 1326–1336. (IF: 5.089; Citation: 9)

  17. Cepinska M, Veenhuis M, van der Klei IJ, Nagotu S$. (2011) Peroxisome fission is associated with reorganization of specific membrane proteins. Traffic.12: 925-37. (IF: 4.714; Citation: 15)

  18. Nagotu S, Veenhuis M, van der Klei IJ. (2010) Divide et impera: the dictum of peroxisomes. Traffic. 11:175-84. (IF: 4.714; Citation: 29)

  19. Nagotu S, Krikken AM, Otzen M, Kiel JA, Veenhuis M, van der Klei IJ. (2008) Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1, two proteins also involved in mitochondrial fission. Traffic. 9: 1471–1484. (IF: 4.714; Citation: 31)

  20. Nagotu S, Saraya R, Otzen M, Veenhuis M, van der Klei IJ. (2008) Peroxisome proliferation in Hansenula polymorpha requires Dnm1p which mediates fission but not de novo formation. Biochim Biophys Acta – Molecular Cell Research. 1783: 760–769. (IF: 5.297; Citation: 58)

  21. Otzen M, Krikken AM, Ozimek PZ, Kurbatova E, Nagotu S, Veenhuis M, van der Klei IJ. (2006) In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins. FEMS Yeast Res. 6: 1157–1166. (IF: 2.436; Citation: 22)

  22. Kuravi K*, Nagotu S*, Krikken AM, Sjollema K, Deckers M, Erdmann R, Veenhuis M, van der Klei IJ (2006). Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. J Cell Sci. 119: 3994–4001. (IF: 5.325; Citation: 106)

* These authors have contributed equally to this manuscript. 

$Corresponding author.

Impact factor (IF) is based on year 2013.

PRESENTATIONS  

  1. October 2014: Oral presentation – Peroxisome biogenesis in yeast - unplugging the division machinery, IIT Ropar, Ropar, India

  2. December 2011: Oral presentation – Peroxisome biogenesis: the role of Pex34 at Peroxisome symposium, Bochum, Germany.

  3. October 2011: Oral presentation – Peroxisome biogenesis in yeast, LIMES, Bonn.

  4. February 2011: Oral presentation – “Dnm1-related organelle fission machinery – are more factors involved?” at Humboldt Network meeting, Göttingen, Germany.

  5. October 2010: Chair for the session “Peroxisome biogenesis” at Open European Peroxisome Meeting (OEPM) meeting, Amsterdam, The Netherlands.

  6. December 2009: Oral presentation – “Organelle fission machinery – shared by peroxisomes and mitochondria” Symposium, Bochum, Germany.

  7. December 2008: Poster presentation – “Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1 two proteins also involved in mitochondrial fission” at ASCB Annual meeting, San Francisco, USA.

  8. October 2008: Oral presentation – "Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1 two proteins also involved in mitochondrial fission" at Peroxisome meeting, Bochum, Germany.

  9. September 2008: Poster presentation – "Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1 two proteins also involved in mitochondrial fission" at GBB symposium, Groningen, the Netherlands.

  10. January 2008: Oral presentation – “Mitochondrial and peroxisome fission is mediated by one organelle fission machinery” at EMBN Workshop – Membrane Proteins and Proteomics, Groningen, the Netherlands.

  11. September 2007: Poster presentation – "Peroxisome proliferation in Hansenula polymorpha requires Dnm1p which mediates fission but not de novo formation” at GBB symposium, Groningen, the Netherlands.

  12. March 2007: Poster presentation – “Peroxisome fission in the yeast Hansenula polymorpha involves the dynamin related protein Dnm1p” at FEBS Advance lecture course, Maratea, Italy.

  13. September 2006: Oral presentation – "Two dynamin-like-proteins Vps1p and Dnm1p play a role in peroxisome proliferation in yeast" at Open European Peroxisome Meeting (OEPM), Leuven, Belgium.

  14. June 2006: Oral presentation – “The dynamin-like-proteins Vps1p and Dnm1p play a role in peroxisome proliferation in Saccharomyces cerevisiae” at Yeasterday: Leiden, The Netherlands.

  15. March 2006: Poster presentation – “The dynamin-like-proteins Vps1p and Dnm1p play a role in peroxisome proliferation in Saccharomyces cerevisiae” at NWO-CW study group Lipids and Biomembranes, Lunteren, the Netherlands.

  16. Aug 2004: Oral presentation – “Disruption of hydrophobic interactions: a probable cause of water stress in Pseudomonas putida” at International Students Symposium at the International Max Plank Research Institute, Cologne, Germany.

 

 
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