CH 221	Organic Chemistry	3-1-0-8
Syllabus: Introduction to types of organic reactions; Structure and stability of reactive intermediates: carbocations, carbanions, free radicals, carbenes, arynes and nitrenes; Methods of determining organic reaction mechanism: thermodynamic and kinetic requirements, transition state theory, Hammond postulate, Curtin-Hammett principle, kinetic vs. thermodynamic control reaction, isotope effects, substituent effects, Hammett linear free energy relationship, Taft equation; Addition reaction to C=C and C=O; Preliminary idea of radical reactions; Application of Oxidation and Reduction reactions and reagents, Name reactions (e.g. Sharpless epoxidation, Suzuki coupling, Heck coupling etc.). Mechanism of aromatic nucleophilic and electrophilic substitions; Introduction to synthesis of nucleic acids and peptide chemistry. Texts: 1. E. V. Anslyn and D. A. Dougherty, Modern Physical Organic Chemistry, 1^st Ed., University Science Books, California ,2006. 2. F. A. Carey and R. J. Sundberg, Advanced Organic Chemistry: Structure and Mechanisms  (Part A and B), Kluwer Academic/ Plenum Pub., 2000 References: 1. P. Sykes, A guide to mechanism in Organic Chemistry, 6^th Ed., Pearson Education, 2004. 2. M. B. Smith and J. March, Advanced Organic Chemistry, 6^th Ed.., John Wiley and Sons, Inc, 2007. 3. D. Nasipuri, Stereochemistry of Organic Compounds, Wiley, 1994.