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Switch-Peptides:  Controlling Self-Assembly of Amyloid β-Derived Peptides in vitro by Consecutive Triggering of Acyl Migrations

Ecole Polytechnique Fédérale de Lausanne (EPFL), Institute of Chemical Sciences and Engineering, CH-1015 Lausanne, Switzerland
J. Am. Chem. Soc., 2005, 127 (34), pp 11888–11889
DOI: 10.1021/ja052083v
Publication Date (Web): August 10, 2005
Copyright © 2005 American Chemical Society


Abstract Image

The sequential triggering (SoffSon) of O, N-acyl migrations (AcM) by chemical and enzymatic methods (Ti) in peptides containing structure-disrupting switch-elements, S (switch-peptides), offers a novel tool for studying in statu nascendi the onset and inhibition of polypeptide folding and self-assembly as a key process in degenerative diseases.

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  • Published In Issue: August 31, 2005
  • Received April 1, 2005