• Alzheimer’s disease;
  • circular dichroism;
  • protein folding;
  • protein structures;
  • switch peptides
Thumbnail image of graphical abstract

A novel concept for triggering conformational transitions, and thus changes in structure and function, in peptides with a switching element S provides intriguing perspectives for studying molecular processes (see scheme) that play a key role, for example, in early events of Alzheimer's disease.