Department of Biosciences and Bioengineering, IIT Guwahati


Research Interests






Citations at Google Scholar

Documents at Figshare




















Research Articles:


Dutta P., Devaraj V., Bose B. A Negative Feedback Regulates The Flow Of Signal Through Akt/mTORC1/S6K1 Pathway. bioRxiv 147710; doi:

Journal articles:

Agarwal M, Sahoo AK, Bose B. Receptor-Mediated Enhanced Cellular Delivery of Nanoparticles Using Recombinant Receptor-Binding Domain of Diphtheria Toxin. Mol  Pharm. 2016 Dec 13 [Epub ahead of print]  [PMID: 27959571]

Loying P, Manhas J, Sen S, Bose B. Autoregulation and Heterogeneity in Expression of Human Cripto-1. PLoS ONE. 2015 10(2): e0116748 [PMID: 25658584]

Thakur R, Kumar A, Bose B, Panda D, Saikia D, Chattopadhyay P, Mukherjee AK. A new peptide (Ruviprase) purified from the venom of Daboia russelii russelii shows potent anticoagulant activity via non-enzymatic inhibition of thrombin and factor Xa. Biochimie. 2014  105:149-58 [PMID: 25038567]

Kumar A, Das G, Bose B. Recombinant Receptor-binding Domain of Diphtheria Toxin Increases Potency of Curcumin by Enhancing Cellular Uptake. Mol Pharm. 2013 11(1): 208-17  [PMID: 24224661

Bose B. Systems biology: A biologist's viewpoint. Prog Biophys Mol Biol. 2013 113(3): 358-68 [PMID: 23872085 ]

Das AB, Loying P, Bose B. Human recombinant Cripto-1 increases doubling time and reduces proliferation of HeLa cells independent of pro-proliferation pathways. Cancer Lett. 2012 318(2): 189-98  [PMID: 22182448]

Bose B, Khanna N., Acharya S.K., Sinha S. Generation and characterization of a single gene mouse-human chimeric antibody against hepatitis B surface antigen. J Gastroenterol Hepatol. 2006 21(9): 1439-47. [PMID: 16911690]

Bose B, Khanna N., Acharya S.K., Sinha S. Generation and characterization of a chimeric antibody against Hepatitis B surface antigen.
Biotechnol Appl Biochem. 2006 43(Pt 2):93-101. [PMID: 16253117]

Bose B, Khanna N., Acharya S.K., Sinha S. A high affinity mouse-human chimeric Fab against Hepatitis B surface antigen. World J Gastroenterol. 2005 11(48):7569-78.
[PMID: 16437680]

Bose B, Sinha S. Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen driven affinity selection. Immunology. 2005 116(2):172-83.
[PMID: 16162266]

Bose B, Chugh D.A., Kala M., Acharya S.K., Khanna N., Sinha S. Characterization and molecular modeling of a highly stable anti-Hepatitis B surface antigen scFv. Mol Immunol. 2003 40(9):617-31. 
[PMID: 14597165]


"A recombinant Mouse-Human chimeric Fab against Hepatitis B surface antigen"  -Subrata Sinha, Biplab Bose, Navin khanna, Subrat Kumar Acharya. Patent granted: India: 251904; South Africa: ZA2009/04338; Patent Pending: PCT/IN2007/000403.


Loying P., Manhas J., Sen S., Bose B. Cellular Heterogeneity in Expression of an Oncofetal Protein. 83rd Annual Meeting of Society Of Biological Chemists (India), Bhubaneswar, December 2014.

Loying P., Bose B. Exploring Heterogeneity in Expression of Human Cripto-1. International Conference on Disease Biology and Therapeutics-2014(ICDBT2014),  Guwahati, December 2014.

Bose B. All Cells are Equal, But Some are More Equal Than Others. National Seminar on Recent Advances in Biotechnological Research in North East India: Challenges and Prospects, Tezpur University, November 2014.

Loying P., Agarwal M., Bose B. Involvement of Mitogenic Pathways in Expression of Human Cripto-1. 4th International Conference on Stem Cells and Cancer (ICSCC- 2013), Mumbai,  October 2013.

Loying P., Agarwal M., Bose B. Transcriptional Circuit of Human Cripto-1: Exploring Expression Heterogeneity. Cell Signaling in Metabolism, Inflammation and Cancer, Cold Spring Harbor Asia Conferences, China, September 2013.

Kumar A, Bose B Truncated Diphtheria Toxin as a Novel Therapeutic Agent, Carcinogensis 2012, New Delhi, November 2012.

Loying P., Chaturvedi R., Bose B. ‘Design Principle of the Transcriptional Circuit of Human Cripto-1’, 3rd International Conference on Stem Cells and Cancer (ICSCC- 2012), New Delhi,  October 2012.

Mehta T, Bose B. FlowPy: a python tool for extraction of flow cytometry data.  The Eighth Asia Pacific Bioinformatics Conference (APBC2010), Bangalore, January, 2010.

Batra S, Bose B. Effect Of Ligand Mediated Cross-Linking On Lateral Diffusion Of Cell Surface Receptors.  International Conference on Physics Biology Interface (ICPBI 2009),Saha Institute of Nuclear Physics, Kolkata, December, 2009.

Das A. B., Bose B. Heterologous Expression of Human Oncofetal Protein Cripto-1. 77th Annual meeting of Society Of Biological Chemists (India), IIT Madras, Chennai, India, December, 2008.

M. S. Sudarsan, Dwivedi G., Bose B. B Cell Receptor Dynamics: Effect Of Ligand Valency. Integrating Physics, Chemistry, Mathematics and Biology to Understand Living Systems (IPCMB 2008), Bose Institute, Kolkata, India, December, 2008.

Prasanna N.A., Bose B. Molecular Modeling and structural analysis of NS3 Helicase of West Nile Virus. Indo-French Bioinformatics Meeting (IFBM2006), National Center for Biological Sciences, Bangalore, India. June,  2006.