BT 209	Bio-reaction Engineering	2-1-0-6
Pre-requisites: Not Required Syllabus Kinetics of bioreaction: Bioreaction stoichiometry, Lumped stoichiometry in complex systems such as enzymatic bioconversions and cell growth, Homogeneous/Heterogeneous bioreaction, Molecularity, Order, Rate of bioreaction, Elementary and non-elementary bioreaction, Single reactions and reaction networks, Bioreaction network, Reactive intermediates and steady state approximation in bioreaction mechanisms, Rate-limiting step. Rate of bioreaction parameters: Conversion, Experimental data collection and analysis to determine the kinetic parameters for reversible and irreversible bioreactions, Shifting order bioreaction, Temperature effect on rate of bioreaction, Arrhenius equation. Ideal bioreactors: Introduction of bioreactor design: concept of ideal Batch and ideal steady state continuous bioreactors: Continuous stirred tank state bioreactor (CSTR) and plug flow bioreactor (PFR). Design for Single bioreactions: Size comparison of bioreactors: single bioreactors for single reaction, Series and parallel combination of multiple bioreactors for single reaction, Recycle bioreactor, Autocatalytic reaction such as biomass growth. Product distribution and Design for Multiple bioreactions: Multiple bioreaction: series and parallel bioreaction, Design for parallel bioreactions, product distribution, yields, selectivity and bioreactor size, Design for series reaction and successive reactions of shifting orders in different reactors, Combination of irreversible series and parallel bioreaction. Heterogeneous bioreaction: Heterogeneous reaction in bioprocessing, immobilization of cell and enzyme, concentration gradient and reaction rates in immobilized cell and enzyme, internal mass transfer and bioreaction, Thiele modulus and effectiveness factor, external mass transfer. Non-Ideal bioreactor mixing patterns: Basics of non-ideal flow, E, the age distribution of fluid, Residence time distribution (RTD), prediction of conversion, Reactor modeling with RTD, Segregation model, Tanks in series model, Dispersion model. Text Books 1. O. Levenspiel, Chemical Reaction Engineering, 3rd Ed., John Wiley & Sons, Inc. 1999. 2. Doran, Bioprocess Engineering Principles, 2nd Edition, Academic Press, 2014 References 1. H. S. Fogler, Elements of Chemical Reaction ,BT 209 Bio-reaction Engineering, Engineering, Prentice Hall, 2nd Ed., New Jersey, 1992. 2. J. Smith, "Chemical Engineering Kinetics", 3rd edition. McGraw-Hill, (1990). 3. Bailey, J. E., and D. F. Ollis. Biochemical Engineering Fundamentals. 2nd ed. New York, McGraw-Hill, 1986.